Low-gravity process engineering: Difference between revisions

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Microgravity conditions offer unique advantages for various [[biotechnology]] applications.
 
[[Protein crystallization]] in space often results in larger, more well-ordered crystals compared to those grown on Earth. These high-quality crystals are valuable for [[structural biology]] studies and drug design.<ref>{{Cite journal |last1=DeLucas |first1=L. J. |last2=Smith |first2=C. D. |last3=Smith |first3=H. W. |last4=Vijay-Kumar |first4=S. |last5=Senadhi |first5=S. E. |last6=Ealick |first6=S. E. |last7=Carter |first7=D. C. |last8=Snyder |first8=R. S. |last9=Weber |first9=P. C. |last10=Salemme |first10=F. R. |date=1989-11-03 |title=Protein crystal growth in microgravity |url=https://pubmed.ncbi.nlm.nih.gov/2510297/ |journal=Science (New York, N.Y.) |volume=246 |issue=4930 |pages=651–654 |doi=10.1126/science.2510297 |issn=0036-8075 |pmid=2510297|bibcode=1989Sci...246..651D }}</ref> The microgravity environment reduces sedimentation and convection, allowing for more uniform crystal growth.<ref>{{Cite journal |last1=McPherson |first1=Alexander |last2=DeLucas |first2=Lawrence James |date=2015-09-03 |title=Microgravity protein crystallization |url=https://www.nature.com/articles/npjmgrav201510 |journal=npj Microgravity |language=en |volume=1 |issue=1 |pagespage=1–2015010 |doi=10.1038/npjmgrav.2015.10 |pmid=28725714 |pmc=5515504 |issn=2373-8065}}</ref>
 
[[Cell culturing in open microfluidics|Cell culturing]] and tissue engineering benefit from the reduced mechanical stresses in microgravity. This environment allows for [[Three-dimensional space|three-dimensional]] cell growth and the formation of tissue-like structures that more closely resemble [[in vivo]] conditions.<ref>{{Cite journal |last1=Grimm |first1=Daniela |last2=Wehland |first2=Markus |last3=Pietsch |first3=Jessica |last4=Aleshcheva |first4=Ganna |last5=Wise |first5=Petra |last6=van Loon |first6=Jack |last7=Ulbrich |first7=Claudia |last8=Magnusson |first8=Nils E. |last9=Infanger |first9=Manfred |last10=Bauer |first10=Johann |date=2014-04-04 |title=Growing tissues in real and simulated microgravity: new methods for tissue engineering |journal=Tissue Engineering. Part B, Reviews |volume=20 |issue=6 |pages=555–566 |doi=10.1089/ten.TEB.2013.0704 |issn=1937-3376 |pmc=4241976 |pmid=24597549}}</ref> Such studies contribute to our understanding of [[Cell biology|cellular biology]] and may lead to advancements in [[regenerative medicine]].<ref>{{Cite journal |last1=Becker |first1=Jeanne L. |last2=Souza |first2=Glauco R. |date=2013-04-12 |title=Using space-based investigations to inform cancer research on Earth |url=https://www.nature.com/articles/nrc3507 |journal=Nature Reviews Cancer |language=en |volume=13 |issue=5 |pages=315–327 |doi=10.1038/nrc3507 |pmid=23584334 |issn=1474-1768}}</ref>