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Line 48: ===In vivo stretchable MEAs=== Stretchable MEAs have many benefits for [[~~implant~~Implant (medicine)\| implantable]] in vivo applications for recording and stimulation of electrophysiological activity from electrogenic biological tissues (most commonly neurons and muscles). Some applications involve only recording of electrophysiological activity, e.g., on the surface of the brain <ref>Weltman, A., et al. "Flexible MEA for Retinal Recording and Stimulation." Journal of Neural Engineering, vol. 17, no. 5, 2020, p. 056025. IOP Science, iopscience.iop.org/article/10.1088/1741-2552/abb4a5/meta. Accessed 10 Nov. 2024. </ref>, the spinal cord <ref>Meacham, Kathleen W., et al. "A Lithographically-Patterned, Elastic Multi-Electrode Array for Surface Stimulation of the Spinal Cord." Biomedical Microdevices, vol. 10, no. 2, 2008, pp. 259-269. Springer Link, link.springer.com/article/10.1007/s10544-007-9132-9. Accessed 10 Nov. 2024.</ref>, some involve only stimulation of electrophysiological activity, and some both <ref>Rowan, Cami C., et al. "A Microclip Peripheral Nerve Interface (μcPNI) for Bioelectronic Interfacing with Small Nerves." Advanced Science, vol. 8, no. 24, 2021, p. 2102945. Wiley Online Library, onlinelibrary.wiley.com/doi/full/10.1002/advs.202102945. Accessed 10 Nov. 2024.</ref>. ====Advantages==== The main benefits of using sMEAs for [[in vivo]] applications are twofold. First, they can [[conform]] to the dynamic and often curved surfaces of biological tissues. Second, sMEAs cause significant smaller [[foreign body reaction]] than rigid MEAs because of the reduced mismatch in mechanical properties ([[stiffness]]) between the [[Implant (medicine)\|implant]] the tissue. ====Disadvantage====

Stretchable microelectrode array: Difference between revisions