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|-
!rowspan=2| 1 || 2
| [[Aidan Hutchinson]] || [[Defensive end]] || [[Michigan Wolverines football|Michigan]]
| [[Aidan Hutchinson]] || [[Defensive end]] || [[Michigan Wolverines football|Michigan]] || || <ref>{{Cite web |title=Lions select Michigan DE Aidan Hutchinson with No. 2 pick of 2022 NFL Draft |url=https://www.nfl.com/news/lions-select-michigan-de-aidan-hutchinson-with-no-2-pick-of-2022-nfl-draft |access-date=29 April 2022 |website=NFL.com}}</ref><ref>{{Cite web |title=Lions draft defensive end Aidan Hutchinson |url=https://www.detroitlions.com/news/lions-draft-defensive-end-aidan-hutchinson |access-date=29 April 2022 |website=www.detroitlions.com}}</ref><ref>{{Cite web |title=Aidan Hutchinson Draft and Combine Prospect Profile |url=https://www.nfl.com/prospects/aidan-hutchinson/32004855-5409-9869-e552-bb07ce41f012 |access-date=29 April 2022 |website=NFL.com}}</ref><ref name="Lions picks">{{Cite web |title=2022 NFL Draft {{!}} NFL Draft News, Video & Photos |url=https://www.nfl.com/draft/tracker/teams/detroit-lions/2022 |access-date=29 April 2022 |website=NFL.com}}</ref>
|-
! 12
| [[Jameson Williams]] || [[Wide receiver]] || [[Alabama Crimson Tide football|Alabama]]
| [[Jameson Williams]] || [[Wide receiver]] || [[Alabama Crimson Tide football|Alabama]] || From [[2022 Minnesota Vikings season|Minnesota Vikings]]<ref name="VikingsTrade">{{Cite web |title=Lions trade up to select Alabama WR Jameson Williams at No. 12 |url=https://www.nfl.com/news/lions-trade-up-to-select-alabama-wr-jameson-williams-at-no-12 |access-date=29 April 2022 |website=NFL.com}}</ref> || <ref name="VikingsTrade" /><ref>{{Cite web |title=Lions trade up, draft wide receiver Jameson Williams |url=https://www.detroitlions.com/news/lions-trade-up-draft-wide-receiver-jameson-williams |access-date=29 April 2022 |website=www.detroitlions.com}}</ref><ref>{{Cite web |title=Jameson Williams Draft and Combine Prospect Profile |url=https://www.nfl.com/prospects/jameson-williams/32005749-4c34-4909-bc5e-bde59d1a8826 |access-date=29 April 2022 |website=NFL.com}}</ref><ref name="Lions picks" />
|-
! 2 || 46
| [[Josh Paschal]] || [[Defensive end]] || [[Kentucky Wildcats football|Kentucky]]
| [[Josh Paschal]] || [[Defensive end]] || [[Kentucky Wildcats football|Kentucky]] || From Minnesota Vikings<ref name="VikingsTrade" /> || <ref name="Day2Grades">{{Cite web |title=2022 NFL Draft: Day 2 quick-snap grades for all 32 teams |url=https://www.nfl.com/news/2022-nfl-draft-day-2-quick-snap-grades-for-all-32-teams |access-date=30 April 2022 |website=NFL.com}}</ref><ref>{{Cite web |title=Lions draft defensive end Josh Paschal |url=https://www.detroitlions.com/news/lions-draft-defensive-end-josh-paschal |access-date=30 April 2022 |website=www.detroitlions.com}}</ref><ref>{{Cite web |title=Joshua Paschal Draft and Combine Prospect Profile |url=https://www.nfl.com/prospects/joshua-paschal/32005041-5306-8486-93fc-0cae1c9cca7f |access-date=30 April 2022 |website=NFL.com}}</ref><ref name="Lions picks" />
|-
! 3 || 97
| [[Kerby Joseph]] || [[Defensive back]] || [[Illinois Fighting Illini football|Illinois]]
| [[Kerby Joseph]] || [[Defensive back]] || [[Illinois Fighting Illini football|Illinois]] || Compensatory selection{{efn-ua|name=comppicks|[[National Football League draft#Compensatory picks|Compensatory selections]] awarded to the Detroit Lions. Under the rules for compensatory draft selections, a team losing more or better compensatory free agents than it acquires in the previous year is eligible to receive compensatory picks. Compensatory free agents are determined by a formula based on salary, playing time and postseason honors. The formula was developed by the NFL management council. Not every free agent lost or signed by a club is covered by this formula, and no club may receive more than four compensatory picks in any one year.<ref>{{Cite web |title=Lions awarded three compensatory draft picks |url=https://www.detroitlions.com/news/lions-awarded-three-compensatory-draft-picks |access-date=16 March 2022 |website=www.detroitlions.com}}</ref>}} || <ref name="Day2Grades" /><ref>{{Cite web |title=Lions draft safety Kerby Joseph |url=https://www.detroitlions.com/news/lions-draft-safety-kerby-joseph |access-date=30 April 2022 |website=www.detroitlions.com}}</ref><ref>{{Cite web |title=Kerby Joseph Draft and Combine Prospect Profile |url=https://www.nfl.com/prospects/kerby-joseph/32004a4f-5322-3092-7893-b61e9a57cf3b |access-date=30 April 2022 |website=NFL.com}}</ref><ref name="Lions picks" />
|-
! 5 || 177
| [[James Mitchell (giocatore di football americano)|James Mitchell]] || [[Tight end]] || [[Virginia Tech Hokies football|Virginia Tech]]
| [[James Mitchell (giocatore di football americano)|James Mitchell]] || [[Tight end]] || [[Virginia Tech Hokies football|Virginia Tech]] || Compensatory selection{{efn-ua|name=comppicks}} || <ref>{{Cite web |title=2022 NFL Draft: Pick-by-pick analysis for Day 3, Rounds 4-5 |url=https://www.nfl.com/news/2022-nfl-draft-pick-by-pick-analysis-for-day-3-rounds-4-5 |access-date=2 May 2022 |website=NFL.com}}</ref><ref>{{Cite web |title=Lions draft tight end James Mitchell |url=https://www.detroitlions.com/news/lions-draft-tight-end-james-mitchell |access-date=2 May 2022 |website=www.detroitlions.com}}</ref><ref>{{Cite web |title=James Mitchell Draft and Combine Prospect Profile |url=https://www.nfl.com/prospects/james-mitchell/32004d49-5433-2595-1036-880278848904 |access-date=2 May 2022 |website=NFL.com}}</ref><ref name="Lions picks" />
|-
!rowspan=2| 6 || 188
| [[Malcolm Rodriguez]] || [[Linebacker]] || [[Oklahoma State Cowboys football|Oklahoma State]]
| [[Malcolm Rodriguez]] || [[Linebacker]] || [[Oklahoma State Cowboys football|Oklahoma State]] || From [[Seattle Seahawks]] || <ref name="Round6and7">{{Cite web |title=2022 NFL Draft: Pick-by-pick analysis for Day 3, Rounds 6-7 |url=https://www.nfl.com/news/2022-nfl-draft-pick-by-pick-analysis-for-day-3-rounds-6-7 |access-date=2 May 2022 |website=NFL.com}}</ref><ref>{{Cite web |title=Lions trade down, draft LB Malcolm Rodriguez |url=https://www.detroitlions.com/news/lions-trade-down-draft-lb-malcolm-rodriguez |access-date=2 May 2022 |website=www.detroitlions.com}}</ref><ref>{{Cite web |title=Malcolm Rodriguez Draft and Combine Prospect Profile |url=https://www.nfl.com/prospects/malcolm-rodriguez/3200524f-4468-8025-e312-d977094cdc1f |access-date=2 May 2022 |website=NFL.com}}</ref><ref name="Lions picks" />
|-
! 217
| [[James Houston]] || [[Linebacker]] || [[Jackson State Tigers football|Jackson State]]
| [[James Houston]] || [[Linebacker]] || [[Jackson State Tigers football|Jackson State]] || Compensatory selection{{efn-ua|name=comppicks}}|| <ref name="Round6and7" /><ref>{{Cite web |title=Lions draft OLB James Houston |url=https://www.detroitlions.com/news/lions-draft-olb-james-houston |access-date=2 May 2022 |website=www.detroitlions.com}}</ref><ref>{{Cite web |title=James Houston Draft and Combine Prospect Profile |url=https://www.nfl.com/prospects/james-houston/3200484f-5546-0710-2211-95488cd5c2bb |access-date=2 May 2022 |website=NFL.com}}</ref><ref name="Lions picks" />
|-
! 7 || 237
| [[Chase Lucas]] || [[Cornerback]] || [[Arizona State Sun Devils football|Arizona State]]
| [[Chase Lucas]] || [[Cornerback]] || [[Arizona State Sun Devils football|Arizona State]] || From [[New Orleans Saints]]|| <ref name="Round6and7" /><ref>{{Cite web |title=Lions draft CB Chase Lucas |url=https://www.detroitlions.com/news/lions-draft-cb-chase-lucas |access-date=2 May 2022 |website=www.detroitlions.com}}</ref><ref>{{Cite web |title=Chase Lucas Draft and Combine Prospect Profile |url=https://www.nfl.com/prospects/chase-lucas/32004c55-4305-2326-cf66-8cd5e58ec23e |access-date=2 May 2022 |website=NFL.com}}</ref><ref name="Lions picks" />
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|}
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