Daniel arap Moi sposò Lena Moi (nata Helena Bommet) nel 1950, ma si separarono nel 1974. Per questo [[Ngina Kenyatta|"Mama Ngina"]], la moglie di Jomo Kenyatta, mantenne lo status di first lady. Lena morì nel 2004. Daniel arap Moi ha otto figli, cinque maschi e tre femmine. Tra questi vi è [[Gideon Moi]], attualmente membro del parlamento in rappresentanza Baringo Central constituency, a seat once held by his father. He also wields the most influence with his father who still has considerable clout in KANU party, the former ruling party in Kenya, of which Gideon is a member.[5] Jonathan Toroitich (un pilota di [[rally]]) e Philip Moi (ufficiale dell'esercito in ritiro). <ref>Ghanaweb.com, April 15, 2005: [http://www.ghanaweb.com/GhanaHomePage/NewsArchive/printnews.php?ID=79319 DOCUMENT: Rawlings' Speech at the APARC]</ref><ref>The Standard, August 1, 2004: [http://www.eastandard.net/archives/august/sun01082004/headlines/news31070401.htm Humble in life, great in death]</ref>. His older and only brother William Tuitoek died in 1995 <ref>Daily Nation, January 28, 2002: [http://www.nationaudio.com/elections/moisuccession/Moi%20Sunset/story4.htm A choice of seven grand homes: Which will Moi opt for?]</ref>