Open Notebook Science Challenge: Difference between revisions

Revision as of 16:41, 7 June 2009

Revision as of 17:42, 1 December 2011

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[[Image:PCAChemicalSpace.png|thumb|PCA Chemical Space for Ethanol]]

[[Image:DescriptorChemicalSpace.png|thumb|Descriptor Chemical Space for THF: ALOGP vs. MW]]

The '''Open Notebook Science Challenge''' is a [[Crowdsourcingcrowdsourcing]] research project<ref name="ONS Challenge">[http://onschallenge.wikispaces.com/ Open Notebook Science Challenge]</ref> which collects measurements of the non-aqueous solubility of organic compounds and publishes these as [[Openopen Datadata]]; findings are reported in an [[Openopen Notebooknotebook Sciencescience]] manner. Although anyone may contribute research data, the competition is only open to post-secondary students in the USA and UK.

The challenge in turn forms part of the UsefulChem project, an ongoing [[Openopen Notebooknotebook Sciencescience]] effort to synthesize and screen potential new anti-malarial drugs<ref name="UsefulChem">[http://usefulchem.wikispaces.com/ UsefulChem]</ref>. Data from the Solubility Challenge will be used to build predictive computational models of solubility for use in optimising syntheses<ref name="predictions">[http://rguha.wordpress.com/2009/01/14/ons-solubility-predictions/ ONS solubility modeling and prediction]</ref>.

The challenge began on September 28, 2008<ref name="began">[http://usefulchem.blogspot.com/2008/09/open-notebook-science-challenge.html The beginning of the Open Notebook Science challenge]</ref> and, as of April 2009, involves researchers and their students from at least 4 different institutions<ref name="experiments">[http://onschallenge.wikispaces.com/list+of+experiments List of experiments]</ref> and has resulted in the acquisition of over 400 solubility measurements<ref name=measurements>[http://oru.edu/cccda/sl/chemspace/cs.php Solubility of Organic Compounds in Organic Solvents]</ref>.

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To encourage participation, each month an award<ref name="award">[http://www.oru.edu/news/view_news.php?id=1010 A News Story Discussing the Awards]</ref> is given to the student who does, in the opinion of the judges<ref name="judges">[http://onschallenge.wikispaces.com/judges ONS Challenge judges]</ref>, the best work. In order to participate, students have to be a US or UK resident<ref name="rules">[http://onschallenge.wikispaces.com/submetaawards08 ONS Challenge Rules]</ref>. The award is a US$500 cash prize. The first three winners also received a year's subscription to the journal [[Nature]]. The awards are sponsored by [[Submeta]]<ref name="submeta">[http://www.submeta.org/index.html submeta]</ref> and Nature.

== Request an Experimentexperiment ==

As well as concentrating on compounds related to the [[Ugi reaction]], the ONSchallenge allows anyone to request a solubility measurement experiment.<ref name="request">[http://oru.edu/cccda/sl/solubility/solubility.php request a solubility measurement experiment]</ref>

== Chemical Donationsdonations ==

[[Sigma Aldrich]] is also an official sponsor of the Open Notebook Science challengeChallenge. Sigma Aldrich is participating by donating and shipping requested chemicals to any experimenters in the US or UK<ref ="Sigma">[http://usefulchem.blogspot.com/2009/02/sigma-aldrich-ships-ons-solubility.html Sigma Aldrich's involvement with the ONS challenge]</ref> for free.

==References==

<references />

== External links ==

* [http://onschallenge.wikispaces.com/ Open Notebook Science Challenge]

[[Category:Open access]]