Microprocessor complex subunit DGCR8: Difference between revisions

Revision as of 16:07, 9 November 2010

Revision as of 09:42, 6 March 2011

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'''Pasha''', also known as '''DGCR8''', is a [[protein]] localized to the [[cell nucleus]] that is required for [[microRNA]] processing. It binds to [[Drosha]], an [[RNase III]] [[enzyme]], to form the ''Microprocessor complex'' that cleaves a [[primary transcript]] known as pri-miRNA to a characteristic [[stem-loop]] structure known as a pre-miRNA, which is then further processed to [[miRNA]] fragments by the enzyme [[Dicer]]. Pasha contains an [[RNA]]-binding ___domain and is thought to bind pri-miRNA to stabilize it for processing by Drosha.

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==References==

* Yeom KH, Lee Y, Han J, Suh MR, Kim VN. (2006). Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing. ''Nucleic Acids Res'' 34(16):4622-9.

{{protein-stub}}

[[Category:Proteins]]

[[Category:MicroRNA]]