G-CSF factor stem-loop destabilising element: Difference between revisions

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Revision as of 11:01, 12 April 2014

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The '''G-CSF factor stem-loop destabilising element (SLDE)''' is an [[cis-regulatory element|RNA element]] secreted by [[fibroblast]]s and endothelial cells in response to the inflammatory mediators [[interleukin-1]] (IL-1) and [[tumour necrosis factor-alpha]] and by activated [[macrophage]]s. The synthesis of G-CSF is regulated both [[transcription (genetics)|transcriptionally]] and through control of [[mRNA]] stability. In unstimulated cells G-CSF mRNA is unstable but becomes stabilised in response to IL-1 or tumour necrosis factor alpha, and also in the case of [[monocyte]]s and macrophages, in response to [[lipopolysaccharide]]. It is likely that the presence of the SLDE in the G-CSF mRNA contributes to the specificity of regulation of G-CSF mRNA and enhances the rate of shortening of the [[polyadenylation|poly(A) tail]].<ref>{{cite journal | last = Putland | first = RA | coauthors author2= Sassinis TA, |author3=Harvey JS, |author4=Diamond P, |author5=Coles LS, |author6=Brown CY, |author7=Goodall GJ | year = 2002 | title = RNA destabilization by the granulocyte colony-stimulating factor stem-loop destabilizing element involves a single stem-loop that promotes deadenylation | journal = Mol Cell Biol | volume = 22 | pages = 1664&ndash;1673 | pmid = 11865046 | doi = 10.1128/MCB.22.6.1664-1673.2002 | issue = 6 | pmc = 135610}}</ref>

==References==