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SSAP originally produced only pairwise alignments but has since been extended to multiple alignments as well.<ref name="taylor">{{cite pmid|7849601}}</ref> It has been applied in an all-to-all fashion to produce a hierarchical fold classification scheme known as [[CATH]] (Class, Architecture, Topology, Homology),.<ref name="Orengo1997">{{cite journal |author=Orengo CA, Michie AD, Jones S, Jones DT, Swindells MB, Thornton JM |title=CATH--a hierarchic classification of protein ___domain structures |journal=Structure |volume=5 |issue=8 |pages=1093–1108 |year=1997 |pmid=9309224 |doi=10.1016/S0969-2126(97)00260-8}}</ref> which has been used to construct the [http://www.cathdb.info/latest/index.html CATH Protein Structure Classification] database.
Generally, SSAP scores above 80 are associated with highly similar structures. Scores between 70 and 80 indicate a similar fold with minor variations. Structures yielding a score between 60 and 70 do not generally contain the same fold, but usually belong to the same protein class with common structural motifs.<ref name="porwal">{{cite pmid|17450548}}</ref>
==See also==
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