X-linked dominant inheritance: Difference between revisions

Revision as of 17:44, 22 July 2012

Revision as of 10:58, 6 August 2012

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When the father alone is the carrier of a defective gene associated with a disease or disorder, he too will have the disorder. His children will inherit the disorder as follows:

*Of his daughters: 100% will have the disorder, since all of his daughters will receive one copy of his single X chromosome.

*Of his sons: none will have the disorder; sons do not receive an X chromosome from their father.

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If both parents were carriers of a defective gene associated with a disease or disorder, they would both have the disorder. Their children would inherit the disorder as follows:

*Of their daughters: 100% will have the disorder, since all of the daughters will receive a copy of their father's X chromosome.

*Of the sons: 50% will have the disorder, 50% will be completely unaffected. Sons have an equal chance of receiving either of their mother's X chromosomes.

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*Most cases of [[Alport syndrome]]<ref>The more frequent presentation of Alport Syndrome appear from mutations in the COL4A5 gene, which are inherited in an X-linked dominant form; see Jais JP et al. [http://jasn.asnjournals.org/content/14/10/2603.long X-Linked Alport Syndrome: Natural History and Genotype-Phenotype Correlations in Girls and Women Belonging to 195 Families: A “European Community Alport Syndrome Concerted Action” Study] J Am Soc Nephrol. 2003 Oct;14(10):2603-10. Accessed 27 May 2012.</ref>

*Incontinentia pigmenti{{citation needed|date=May 2012}}

*[[Giuffrè–Tsukahara syndrome]]<ref name=Giuffrè>{{cite journal|last=Ashwin|first=B. Dalal|coauthors=Anujit Sarkar, T. Padma Priya, Madhusudan R. Nandineni|title=Giuffrè–Tsukahara syndrome: Evidence for X-linked dominant inheritance and review|journal=American Journal of Medical Genetics Part A|year=2010|volume=152A|issue=8|pages=2057–2060|doi=10.1002/ajmg.a.33505|accessdate=10 May 2012}}</ref>

*[[Charcot–Marie–Tooth disease]]<ref name=Neurology>{{cite journal|last=Yiu|first=E.M.|coauthors=N. Geevasinga, G.A. Nicholson, E.R. Fagan, M.M. Ryan, R.A. Ouvrier|title=A retrospective review of X-linked Charcot-Marie-Tooth disease in childhood|journal=Neurology|date=1|year=2011|month=February|volume=76|issue=5|pages=461-466461–466|doi=10.1212/WNL.0b013e31820a0ceb|accessdate=11 May 2012}}</ref>

==See also==

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{{X-linked disorders}}

[[categoryCategory:X-linked dominant disorders| ]]

[[it:Ereditarietà eterosomica dominante]]