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== Pathophysiology ==
Normal [[collagen]] synthesis depends upon the [[hydroxylation]] of [[proline]] and [[lysine]] to form [[hydroxyproline]] and [[hydroxylysine]], respectively. These nonstandard [[amino acids]] are found abundantly in collagen and confer strength to collagen fibrils. [[Prolyl hydroxylase|Prolyl]] and [[lysyl hydroxylase]], the enzymes that catalyzes the hydroxylation, require [[vitamin C]]. Without it, hydroxyproline and hydroxylysine are not formed, and the resulting collagen fibrils are considerably weaker than normal.
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== See also ==
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