X-linked dominant inheritance: Difference between revisions

Revision as of 19:05, 2 October 2012

Revision as of 20:01, 10 November 2012

Line 5:

X-linked dominant traits do not necessarily affect males more than females (unlike [[X-linked recessive]] traits). The exact pattern of inheritance varies, depending on whether the father or the mother has the trait of interest. All daughters of an affected father will also be affected but none of his sons will be affected (unless the mother is also affected). In addition, the mother of an affected son is also affected (but not necessarily the other way round).

Some scholars have suggested discontinuing the terms dominant and recessive when referring to X-linked inheritance due to the multiple mechanisms that can result in the expression of X-linked traits in females, which include cell autonomous expression, skewed X-inactivation, clonal expansion, and somatic mosaicism.<ref>http://www.ncbi.nlm.nih.gov/pubmed/{{Cite pmid|15316978}}</ref>

==Genetics==