Role of cell adhesions in neural development: Difference between revisions

Revision as of 09:40, 13 April 2013

Revision as of 17:56, 29 April 2013

Line 58:

Several debilitating diseases are brought about from errors in neural development due in part to problems involving neural cell adhesions and adhesion mechanisms.

*CRASH syndrome (or L1 syndrome) is brought about by a mutation in the L1CAM gene on the x-[[chromosome]], resulting in a malfunctioning L1CAM protein. CRASH (acronym) syndrome include the conditions:<ref name="pmid8556302">{{cite journal |author=Fransen E, Lemmon V, Van Camp G, Vits L, Coucke P, Willems PJ |title=CRASH syndrome: clinical spectrum of corpus callosum hypoplasia, retardation, adducted thumbs, spastic paraparesis and hydrocephalus due to mutations in one single gene, L1 |journal=European Journal of Human Genetics |volume=3 |issue=5 |pages=273–84 |year=1995 |pmid=8556302 }}</ref><ref name="pmid7562969">{{cite journal |author=Ruiz JC, Cuppens H, Legius E, ''et al.''|title=Mutations in L1-CAM in two families with X linked complicated spastic paraplegia, MASA syndrome, and HSAS |journal=Journal of medical genetics |volume=32 |issue=7 |pages=549–52 |year=1995 |month=July |pmid=7562969 |pmc=1050549 |doi= 10.1136/jmg.32.7.549|url=}}</ref>

{| class="wikitable"<ref name="pmid7562969">{{cite journal |author=Ruiz JC, Cuppens H, Legius E, ''et al.''|title=Mutations in L1-CAM in two families with X linked complicated spastic paraplegia, MASA syndrome, and HSAS |journal=Journal of medical genetics |volume=32 |issue=7 |pages=549–52 |year=1995 |month=July |pmid=7562969 |pmc=1050549 |doi= 10.1136/jmg.32.7.549|url=}}</ref>

{{Table

|type=class="wikitable sortable"

|title=

|hdrs=!!

|row1= {{!!}}

|row2= {{!!}} }}

{{Table