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==Empirical evidence that randomization makes a difference==
Empirically differences between randomized and non-randomized studies,<ref>{{cite journal|doi=10.1002/14651858.MR000034.pub2|author=Anglemyer A, Horvath HT, Bero L|title=Healthcare outcomes assessed with observational study designs compared with those assessed in randomized trials|journal=Cochrane Database Syst Rev|date=April 2014|pmid=24782322}}</ref> and between adequately and inadequately randomized trials have been difficult to detect <ref>{{cite journal|doi=10.1002/14651858.MR000012.pub3 |
.<ref>{{cite journal|doi=10.1186/1745-6215-15-480|author=Howick J, Mebius A|title=In search of justification for the unpredictability paradox|journal=Trials|year=2014|volume=15|pmid=25490908}}</ref>
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