Sequential structure alignment program: Difference between revisions

Revision as of 01:21, 28 August 2015

Revision as of 20:58, 5 June 2016

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| pmid = 7849601

| pmc =2142613

}}</ref> It has been applied in an all-to-all fashion to produce a hierarchical fold classification scheme known as [[CATH]] (Class, Architecture, Topology, Homology),.<ref name="Orengo1997">{{cite journal |authorauthor1=Orengo CA, |author2=Michie AD, |author3=Jones S, |author4=Jones DT, |author5=Swindells MB, |author6=Thornton JM |title=CATH—a hierarchic classification of protein ___domain structures |journal=Structure |volume=5 |issue=8 |pages=1093–1108 |year=1997 |pmid=9309224 |doi=10.1016/S0969-2126(97)00260-8}}</ref> which has been used to construct the [http://www.cathdb.info/latest/index.html CATH Protein Structure Classification] database.

Generally, SSAP scores above 80 are associated with highly similar structures. Scores between 70 and 80 indicate a similar fold with minor variations. Structures yielding a score between 60 and 70 do not generally contain the same fold, but usually belong to the same protein class with common structural motifs.<ref name="porwal">{{Cite journal