'''Hypodermin C''' ({{EC number|3.4.21.49}}, ''Hypoderma collagenase'') is an [[enzyme]].<ref>{{cite journal | title = Chemical and enzymatic characterization of the collagenase from the insect <em>''Hypoderma lineatum</em>'' |author = Lecroisey, A., Boulard, C. and Keil, B. |journal = Eur. J. Biochem. |year = 1979 |volume = 101 |pages = 385–393 |pmid = 230030 |doi=10.1111/j.1432-1033.1979.tb19730.x}}</ref><ref>{{cite journal | title = Specificity of the collagenase from the insect <em>''Hypoderma lineatum</em>'' |author = Lecroisey, A. and Keil, B. |journal = Eur. J. Biochem. |year = 1985 |volume = 152 |pages = 123–130 |pmid = 2995028 |doi=10.1111/j.1432-1033.1985.tb09171.x}}</ref><ref>{{cite journal | title = Complete amino acid sequence of the collagenase from the insect <em>''Hypoderma lineatum</em>'' |author = Lecroisey, A., Gilles, A.-M., De Wolf, A. and Keil, B. |journal = J. Biol. Chem. |year = 1987 |volume = 262 |pages = 7546–7551 |pmid = 3034899}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]
: [[Hydrolysis]] of proteins including native [[collagen]] at -Ala bond leaving an [[N-terminal]] (75%) and a [[C-terminal]] (25%) fragment
