Synthetic genetic array: Difference between revisions

Revision as of 09:07, 17 March 2016

Revision as of 09:25, 17 March 2016

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'''Synthetic Genetic Array analysis''' ('''SGA)''') is a [[high-throughput screening|high-throughput]] technique for exploring [[synthetic lethality|synthetic lethal]] and synthetic sick [[genetic interactions]] ([[Synthetic lethality|SSL]]).<ref name="H. Tong 2001">{{Cite journal

| last1 = Tong | first1 = A. H. Y.

| last2 = Evangelista | first2 = M.

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| pmid = 14764870

| pmc =

}}</ref> The results of this study showed that genes with similar function tend to interact with one another and genes with similar patterns of genetic interactions often encode products that tend to work in the same pathway or complex. Synthetic Genetic Array analysis was initially developed using the model organism ''[[S. cerevisiae]]''. This method has since been extended to cover 30% of the ''S. cerevisiae'' genome.<ref>{{Cite journal

| last1 = Costanzo | first1 = M.

| last2 = Baryshnikova | first2 = A.

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| pmid = 18931302

| pmc =2575475

}}</ref> and ''E. coli''.<ref>{{Cite journal

| doi = 10.1038/nmeth.1240

| last1 = Typas | first1 = A.