Conformational dynamics data bank: Difference between revisions

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}}The '''conformational dynamics data bank''' (CDDB) is a [[database]] about conformational dynamics of [[HeavyImmunoglobulin heavy chain|heavy proteins]] and [[Protein complex|protein assemblies]]. The CDDB is useful when used alongside static structural data to aid research into [[protein function]]. It is also helpful in identifying protein assemblies that are essential to [[Cell (biology)#Functions|cell function]].<ref name=kim>{{cite journal |last=Kim|first=Do-Nyun|authorlink=|author2=Altschuler Josiah |author3=Strong Campbell |author4=McGill Gaël |author5=Bathe Mark |date=Jan 2011|title=Conformational dynamics data bank: a database for conformational dynamics of proteins and supramolecular protein assemblies|journal = Nucleic Acids Res.|volume=39|issue=Database issue|pages=D451-5|publisher= |___location = England| issn = | pmid = 21051356|doi = 10.1093/nar/gkq1088| bibcode = | oclc =| id = | url = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | pmc=3013685}}</ref>

Analysis is carried out by [[Granularity|coarse-grained computation]] of the structures present in the [[electron microscopy data bank]] (EMDB). This analysis shows [[Thermal fluctuations|equilibrium thermal fluctuations]] and [[Elastic and plastic strain|elastic strain]] energy distributions, which allows for identification of rigid and flexible protein domains. The results also provide information on correlations in [[Database of Molecular Motions|molecular motions]] which can be used to identify molecular regions that are highly coupled dynamically.<ref name=kim/>