Transporter Classification Database: Difference between revisions

Revision as of 14:54, 20 January 2017

Revision as of 22:23, 28 November 2017

Line 58:

* 1.A.50 [[phospholamban|Phospholamban (Ca²⁺-channel and Ca²⁺-ATPase regulator) family]]

*1.A.51 The Voltage-gated Proton Channel (VPC) Family

*1.A.52 The Ca2Ca²⁺ Release-activated Ca2Ca²⁺ (CRAC) Channel (CRAC-C) Family

*1.A.53 The Hepatitis C Virus P7 Viroporin Cation-selective Channel (HCV-P7) Family

*1.A.54 The Presenilin ER Ca2Ca²⁺ Leak Channel (Presenilin) Family

*1.A.55 The Synaptic Vesicle-Associated Ca2Ca²⁺ Channel, Flower (Flower) Family

*1.A.56 The Copper Transporter (Ctr) Family

*1.A.57 The Human SARS Caronavirus Viroporin (SARS-VP)

Line 73:

*1.A.65 The Coronavirus Viroporin E Protein (Viroporin E) Family

*1.A.66 The Pardaxin (Pardaxin) Family

*1.A.67 The Membrane Mg2Mg²⁺ Transporter (MMgT) Family

*1.A.68 The Viral Small Hydrophobic Viroporin (V-SH) Family

*1.A.69 The Heteromeric Odorant Receptor Channel (HORC) Family

Line 83:

*1.A.75 The Mechanical Nociceptor, Piezo (Piezo) Family

*1.A.76 The Magnesium Transporter1 (MagT1) Family

*1.A.77 The Mg2Mg<sup>2+</Ca2sup>/Ca²⁺ Uniporter (MCU) Family

*1.A.78 The K⁺-selective Channel in Endosomes and Lysosomes (KEL) Family

*1.A.79 The Cholesterol Uptake Protein (ChUP) or Double Stranded RNA Uptake Family

*1.A.80 The NS4a Viroporin (NS4a) Family

*1.A.81 The Low Affinity Ca2Ca²⁺ Channel (LACC) Family

*1.A.82 The Hair Cell Mechanotransduction Channel (HCMC) Family

*1.A.83 The SV40 Virus Viroporin VP2 (SV40 VP2) Family

*1.A.84 The Calcium Homeostasis Modulator Ca2Ca²⁺ Channel (CALHM-C) Family

*1.A.85 The Poliovirus 2B Viroporin (2B Viroporin) Family

*1.A.86 The Human Papilloma Virus type 16 (HPV16) L2 Viroporin (L2 Viroporin) Family

Line 110:

*1.A.102 Influenza A viroporin PB1-F2 (PB1-F2) Family

*1.A.103 The Simian Virus 5 (Parainfluenza Virus 5) SH (SV5-SH) Family

*1.A.104 The Proposed Flagellar Biosynthesis Na⁺ Channel, FlaH (FlaH) Family

*1.A.105 The Mixed Lineage Kinase Domain-like (MLKL) Family

*1.A.106 The Calcium Load-activated Calcium Channel (CLAC) Family

Line 189:

* 1.D.4 The Tolaasin Channel-forming Family

* 1.D.5 The [[Alamethicin]] or [[Peptaibol]] Antibiotic Channel-forming Family

* 1.D.6 The Complexed Poly 3-Hydroxybutyrate Ca2Ca²⁺ Channel (cPHB-CC) Family

* 1.D.7 The Beticolin Family

* 1.D.8 The [[Saponin]] Family

Line 202:

* 1.D.17 Combinatorially-designed, Pore-forming, β-sheet Peptide Family

* 1.D.18 The Pore-forming Guanosine-Bile Acid Conjugate Family

* 1.D.19 Ca2Ca²⁺ Channel-forming Drug, [[Digitoxin]] Family

* 1.D.20 The Pore-forming Polyene Macrolide Antibiotic/fungal Agent (PMAA) Family

* 1.D.21 The Lipid Nanopore (LipNP) Family

Line 307:

*2.A.3 [[APC superfamily|The Amino Acid-Polyamine-Organocation (APC) Family]]

*2.A.4 [[Cation diffusion facilitator]] (CDF) Family

*2.A.5 [[Ferroportin|Zinc (Zn2Zn²⁺)-Iron (Fe2Fe²⁺) Permease]] Family<ref>[http://opm.phar.umich.edu/families.php?family=873]</ref>

*2.A.6 [[Resistance-nodulation-cell division superfamily|Resistance-Nodulation-Cell Division Superfamily]], see also [[SecDF protein-export membrane protein]]

*2.A.7 The [[Small multidrug resistance protein|Drug/Metabolite Transporter]] (DMT) Superfamily

*2.A.8 The Gluconate:H⁺ Symporter (GntP) Family

*2.A.9 The Membrane Protein Insertase (YidC/Alb3/Oxa1) Family

*2.A.10 The 2-Keto-3-Deoxygluconate Transporter (KdgT) Family

*2.A.11 The Citrate-Mg2Mg²⁺:H⁺ (CitM) Citrate-Ca2Ca²⁺:H⁺ (CitH) Symporter (CitMHS) Family

*2.A.12 [[ATP:ADP antiporter family|ATP:ADP Antiporter Family]]

*2.A.13 The C4-Dicarboxylate Uptake (Dcu) Family

*2.A.14 [[Lactate permease family|Lactate Permease Family]]

*2.A.15 [[Betaine transporter|The Betaine/Carnitine/Choline Transporter (BCCT) Family]]

*2.A.16 [[Tellurite-resistance/dicarboxylate transporter|TeluriteTellurite-resistance/Dicarboxylate Transporter]] Family

*2.A.17 [[Proton-dependent oligopeptide transporter|Proton-dependent Oligopeptide Transporter Family]]

*2.A.18 The Amino Acid/Auxin Permease (AAAP) Family

*2.A.19 The Ca2Ca²⁺:Cation Antiporter (CaCA) Family

*2.A.20 The Inorganic Phosphate Transporter (PiT) Family

*2.A.21 [[Sodium-solute symporter|Solute:Sodium Symporter Family]]

*2.A.22 The [[Neurotransmitter sodium symporter|Neurotransmitter:Sodium Symporter]] Family

*2.A.23 The Dicarboxylate/Amino Acid:Cation (Na⁺ or H⁺) Symporter (DAACS) Family

*2.A.24 The 2-Hydroxycarboxylate Transporter (2-HCT) Family

*2.A.25 [[AGCS family|Alanine or Glycine:Cation Symporter]] (AGCS) Family

*2.A.26 The Branched Chain Amino Acid:Cation Symporter (LIVCS) Family

*2.A.27 The Glutamate:Na⁺ Symporter (ESS) Family

*2.A.28 [[Bile acid:sodium symporter|Bile Acid:Na⁺ Symporter]] Family

*2.A.29 [[Mitochondrial carrier]] Family

*2.A.30 [[Chloride potassium symporter|Cation-Chloride Cotransporter]] (CCC) Family

*2.A.31 [[Anion exchanger family|Anion Exchanger]] Family

*2.A.32 The Silicon Transporter (Sit) Family

*2.A.33 [[Sodium-proton antiporter|NhaA Na⁺:H⁺ Antiporter]] (NhaA) Family

*2.A.34 The NhaB Na⁺:H⁺ Antiporter (NhaB) Family

*2.A.35 The NhaC Na⁺:H⁺ Antiporter (NhaC) Family

*2.A.36 [[Monovalent cation:proton antiporter-1|Monovalent Cation:Proton Antiporter-1]] (CPA1) Family

*2.A.37 [[Monovalent cation:proton antiporter-3|Monovalent Cation:Proton Antiporter-2]] (CPA2) Family

*2.A.38 [[Potassium transporter family|K⁺ Transporter (Trk)]] Family

*2.A.39 [[Nucleobase cation symporter-1|Nucleobase:Cation Symporter-1]] (NCS1) Family

*2.A.40 [[Nucleobase cation symporter-2|Nucleobase:Cation Symporter-2]] (NCS2) Family

Line 347:

*2.A.43 The Lysosomal Cystine Transporter (LCT) Family

*2.A.45 [[Arsenite-antimonite transporter|Arsenite-Antimonite Efflux Family]]

*2.A.46 The Benzoate:H⁺ Symporter (BenE) Family

*2.A.47 [[Divalent anion–sodium symporter|Divalent Anion:Na⁺ Symporter]] (DASS) Family

*2.A.48 The Reduced Folate Carrier (RFC) Family

*2.A.49 [[Chloride channel|Chloride Carrier/Channel]] (ClC) Family

*2.A.50 The Glycerol Uptake (GUP) Family

*2.A.51 The Chromate Ion Transporter (CHR) Family

*2.A.52 The Ni2Ni²⁺-Co2Co²⁺ Transporter (NiCoT) Family

*2.A.53 [[Sulfate permease]] (SulP) Family

*2.A.54 The Mitochondrial Tricarboxylate Carrier (MTC) Family

*2.A.55 [[Natural Resistance-Associated Macrophage Proteins|The Metal Ion (Mn2Mn²⁺-iron) Transporter]] (Nramp) Family

*2.A.56 The Tripartite ATP-independent Periplasmic Transporter (TRAP-T) Family

*2.A.57 The Equilibrative Nucleoside Transporter (ENT) Family

*2.A.58 The Phosphate:Na⁺ Symporter (PNaS) Family

*2.A.59 The Arsenical Resistance-3 (ACR3) Family

*2.A.60 [[Organo anion transporter family|Organo Anion Transporter]] (OAT) Family

*2.A.61 The C4-dicarboxylate Uptake C (DcuC) Family

*2.A.62 The NhaD Na⁺:H⁺ Antiporter (NhaD) Family

*2.A.63 The Monovalent Cation (K⁺ or Na⁺):Proton Antiporter-3 (CPA3) Family

*2.A.64 [[Twin-arginine translocation pathway|Twin Arginine Targeting (Tat) Family]]

*2.A.65 The Bilirubin Transporter (BRT) Family

Line 371:

*2.A.68 The p-Aminobenzoyl-glutamate Transporter (AbgT) Family

*2.A.69 The Auxin Efflux Carrier (AEC) Family

*2.A.70 The Malonate:Na⁺ Symporter (MSS) Family

*2.A.71 The Folate-Biopterin Transporter (FBT) Family

*2.A.72 The K⁺ Uptake Permease (KUP) Family

*2.A.73 The Short Chain Fatty Acid Uptake (AtoE) Family

*2.A.74 The 4 TMS Multidrug Endosomal Transporter (MET) Family

Line 384:

*2.A.81 The Aspartate:Alanine Exchanger (AAEx) Family

*2.A.82 The Organic Solute Transporter (OST) Family

*2.A.83 The Na⁺-dependent Bicarbonate Transporter (SBT) Family

*2.A.84 The Chloroplast Maltose Exporter (MEX) Family

*2.A.85 The Aromatic Acid Exporter (ArAE) Family

Line 397:

*2.A.95 The 6TMS Neutral Amino Acid Transporter (NAAT) Family

*2.A.96 The Acetate Uptake Transporter (AceTr) Family

*2.A.97 The Mitochondrial Inner Membrane K⁺/H⁺ and Ca2Ca²⁺/H⁺ Exchanger (LetM1) Family

*2.A.98 The Putative Sulfate Exporter (PSE) Family

*2.A.99 The 6TMS Ni2Ni²⁺ uptake transporter (HupE-UreJ) Family

*2.A.100 The Ferroportin (Fpn) Family

*2.A.101 The Malonate Uptake (MatC) Family (Formerly UIT1)

Line 406:

*2.A.104 The L-Alanine Exporter (AlaE) Family

*2.A.105 The Mitochondrial Pyruvate Carrier (MPC) Family

*2.A.106 The Ca2Ca²⁺:H⁺ Antiporter-2 (CaCA2) Family

*2.A.107 The MntP Mn2Mn²⁺ exporterExporter (MntP) Family

*2.A.108 The Iron/Lead Transporter (ILT) Family

*2.A.109 The Tellurium Ion Resistance (TerC) Family

*2.A.110 The hemeHeme transporterTransporter, heme-responsive gene protein (HRG) Family

*2.A.111 The Na⁺/H⁺ Antiporter-E (NhaE) Family

*2.A.112 The KX Blood-group Antigen (KXA) Family

*2.A.113 The Nickel/cobalt Transporter (NicO) Family

Line 439:

*2.B.8 The [[Bafilomycin]] A1 (Bafilomycin) Family

*2.B.9 The [[Cell Penetrating Peptide]] (CPP) Functional Family

*2.B.10 The Synthetic CPP, [[Transportan]] Family

*2.B.11 The [[Calcimycin]] or A23187 Carrier-type Ionophore Family

*2.B.12 The [[Salinomycin]] Family

Line 446:

*2.B.15 The Tris-thiourea Tripodal-based Chloride Carrier (TTT-CC) Family

*2.B.16 The Halogen-bond-containing Compound Anion Carrier (HCAC) Family

*2.B.17 The Isophthalaminde Derivative H⁺:Cl^- Co-transporter (IDC) Family

*2.B.18 The Pyridine-2,6-Dicarboxamine Derivative (PDCA) H+:Cl^- Co-transporter Family

*2.B.19 The Calix(4)pyrrole Derivative (C4P) Family

*2.B.20 The Prodigiosin (Prodigiosin) Chloride/Bicarbonate Exchanger Family

*2.B.21 The ortho-Phenylenediamine-bis-Urea Derivative Anion Transporter (oPDA-U) Family

*2.B.22 The Imidazolium-functionalized Anion Transporter (IAT) Family

*2.B.23 The Homotetrameric Transmembrane Zn2Zn<sup>2+</Co2sup>/Co²⁺:Proton Synthetic Antiporter, Rocker (Rocker) Family

*2.B.24 The 2,6-Bis(benzimidazol-2-yl)pyridine Anion Carrier (BBP-AC) Family

*2.B.25 The Peptide-mediated Lipid Flip-Flop (PLFF) Family

Line 466:

====3.A. P-P-bond hydrolysis-driven transporters====

*3.A.1 [[ABC transporter]]s including BtuCD, molybdate uptake transporter, [[Cystic fibrosis transmembrane conductance regulator]] and others

*3.A.2 The H⁺- or Na⁺-translocating [[F-type ATPase]], [[V-type ATPase]] and A-type ATPase superfamily

*3.A.3 [[P-type ATPase|The P-type ATPase]] Superfamily

*3.A.4 [[ArsB and ArsAB transporters|The Arsenite-Antimonite efflux]] family

Line 474:

*3.A.8 The Mitochondrial Protein Translocase (MPT) Family

*3.A.9 The Chloroplast Envelope Protein Translocase (CEPT or Tic-Toc) Family

*3.A.10 [[H+, Na+-translocating pyrophosphatase family|H⁺, Na⁺-translocating Pyrophosphatase]] family

*3.A.11 The Bacterial Competence-related DNA Transformation Transporter (DNA-T) Family

*3.A.12 The Septal DNA Translocator (S-DNA-T) Family

Line 493:

====3.B Decarboxylation-driven transporters====

*3.B.1 The Na⁺-transporting Carboxylic Acid Decarboxylase (NaT-DC) Family

====3.C Methyltransfer-driven transporters====

*3.C.1 The Na⁺ Transporting Methyltetrahydromethanopterin:Coenzyme M Methyltransferase (NaT-MMM) Family

====3.D. Oxidoreduction-driven transporters====

They include a number of transmembrane [[cytochrome b]]-like proteins including [[coenzyme Q - cytochrome c reductase]] (cytochrome bc1 ); [[cytochrome b6f complex]]; formate dehydrogenase, respiratory [[nitrate reductase]]; [[succinate - coenzyme Q reductase]] (fumarate reductase); and [[succinate dehydrogenase]]. See [[electron transport chain]].

*3.D.1 [[NADH:ubiquinone reductase (H+-translocating)|The H⁺ or Na⁺-translocating NADH Dehydrogenase]] ("complex I") family

*3.D.2 The Proton-translocating Transhydrogenase (PTH) Family

*3.D.3 [[Cytochrome c nitrite reductase|The Proton-translocating Quinol:Cytochrome c Reductase]]) Superfamily

*3.D.4 [[Cytochrome c oxidase|Proton-translocating Cytochrome Oxidase]] (COX) Superfamily

*3.D.5 The Na⁺-translocating NADH:Quinone Dehydrogenase (Na-NDH or NQR) Family

*3.D.6 The Putative Ion (H⁺ or Na⁺)-translocating NADH:Ferredoxin Oxidoreductase (NFO or RNF) Family

*3.D.7 The H2H₂:Heterodisulfide Oxidoreductase (HHO) Family

*3.D.8 The Na⁺- or H⁺-Pumping Formyl Methanofuran Dehydrogenase (FMF-DH) Family

*3.D.9 The H⁺-translocating F420H2 Dehydrogenase (F420H2DH) Family

*3.D.10 The Prokaryotic Succinate Dehydrogenase (SDH) Family