Complement component 5: Difference between revisions

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Revision as of 02:01, 4 December 2017

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== Function ==

Complement component 5 is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is composed of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an [[anaphylatoxin]] that possesses potent [[spasm]]ogenic and [[chemotaxis|chemotactic]] activity, is derived from the alpha polypeptide via cleavage with a [[C5 convertase]]. The C5b macromolecular cleavage product can form a complex with the [[complement component 6|C6 complement component]], and this complex is the basis for formation of the membrane attack complex, which includes additional complement components.<ref name="entrez"/>

== Clinical significance ==