Teflon and [[Silicone]] are commonly used [[hydrophobe|hydrophobic]] coatings for coronary guide wires. Hydrophobic coatings have a lower surface energy and reduce friction in the arteries by up to 48%.<ref name=friction/> Hydrophobic coatings do not need to be in contact with fluids to form a slippery texture. Hydrophobic coatings maintain tactile sensation in the artery, allowinggiving doctors full control of the wire at all times and reducing the risk of perforation; though, the coatings are more thrombogenic than hydrophilic coatings.<ref name=techniques/> The thrombogenicity is due to the proteins in the blood adapting to the hydrophobic environment when they adhere to the coating. This causes an irreversible change for the protein, and the protein remains stuck to the coating allowing for a blood clot to form.<ref name=thrombo>{{cite journal |first=Denis |last=Labarre |title=Improving blood compatibility of polymeric surfaces |journal=Trends in Biomaterials & Artificial Organs |year=2001 |volume=15 |issue=1 |pages=1–3 |url=http://www.biomaterials.org.in/ojs/index.php/tibao/article/view/5}}</ref>
==== Magnetic Resonance Compatible Guide Wires ====
