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[[Stephen Barrett]] of [[Quackwatch]] wrote that the advise in the book was impractical and unscientific. For example the authors recommended more than thirty supplements and prescription drugs and for the subject to take a medical examination with more than fifty laboratory tests. The authors made inaccurate statements about [[Multivitamin|vitamin supplements]] and their "presentation of experimental data is biased and uncritical."<ref>[https://www.quackwatch.org/04ConsumerEducation/NegativeBR/le.html "Book Review: Life Extension: A Practical Scientific Approach (1982)"]. [[Quackwatch]]. Retrieved November 22, 2018.</ref>
Nutritionist Kurt Butler has described the book as a
<blockquote>Pearson and Shaw denigrate exercise and claim that all its benefits can be had by taking the pills and remaining sedentary. Many experts believe that following their advice is more likely to accelerate aging rather than retard it. This is because the so-called antioxidants in their regimen are actually redox agents that act as pro-oxidants when taken in the doses the authors recommend, and because exercise is the best proven anti-aging tool available to us.<ref>Butler, Kurt. (1999). ''Lying for Fun and Profit: The Truth about the Media: Exposes the Corrupt Symbiosis Between Media Giants and the Health Fraud Industries''. Health Wise Productions. p. 85. ISBN 978-0967328102</ref></blockquote>
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