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|issue=1 |pages=2542
|doi=10.1038/s41467-018-04964-5
|pmid= 29959318|pmc=6026198 |bibcode=2018NatCo...9.2542S }}</ref> first algorithm whose runtime scales linearly with input set size, very fast, part of [http://mmseqs.org/ MMseqs2] <ref>{{cite journal
|title=MMseqs2 enables sensitive protein sequence searching for the analysis of massive data sets
|author1=Steinegger M. |author2=Söding J. |journal=Nature Biotechnology
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* Skipredudant EMBOSS tool<ref>{{cite web|url=http://bioweb2.pasteur.fr/docs/EMBOSS/skipredundant.html|title=EMBOSS: skipredundant|work=pasteur.fr}}</ref> to remove redundant sequences from a set
* CLUSS Algorithm<ref>{{cite journal|title=CLUSS Algorithm : Clustering non-alignable protein sequences|journal=Prospectus.usherbrooke.ca|volume=8|pages=286|doi=10.1186/1471-2105-8-286|pmid=17683581|pmc=1976428|year = 2007|last1 = Kelil|first1 = Abdellali|last2=Wang|first2=Shengrui|last3=Brzezinski|first3=Ryszard|last4=Fleury|first4=Alain}}</ref> to identify groups of structurally, functionally, or evolutionarily related hard-to-align protein sequences. CLUSS webserver <ref name="prospectus.usherbrooke.ca">{{Cite web | url=http://prospectus.usherbrooke.ca/CLUSS/ | title=CLUSS Home Page}}</ref>
* CLUSS2 Algorithm<ref>{{cite journal|url=https://www.inderscienceonline.com/doi/abs/10.1504/IJCBDD.2008.02019|title=CLUSS2 : Alignment-independent algorithm for clustering protein families with multiple biological functions|issue=2|pages=122–140|journal=International Journal of Computational Biology and Drug Design|volume=1|doi=10.1504/IJCBDD.2008.02019|date=January 2008|last1=Kelil|first1=Abdellali|last2=Wang|first2=Shengrui|last3=Brzezinski|first3=Ryszard|doi-broken-date=
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