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'''Hypodermin C''' ({{EC number|3.4.21.49}}, ''Hypoderma collagenase'') is an [[enzyme]].<ref>{{cite journal | vauthors = Lecroisey A, Boulard C, Keil B | title = Chemical and enzymatic characterization of the collagenase from the insect ''Hypoderma lineatum'' |author1 journal = Lecroisey,European A.Journal |author2of =Boulard, C.Biochemistry |author3 volume =Keil, B.101 |journal issue = Eur.2 J.| Biochem. |yearpages = 1979385–93 |volume date = 101November |issue = 21979 |pages = 385–393 |pmid = 230030 | doi = 10.1111/j.1432-1033.1979.tb19730.x }}</ref><ref>{{cite journal | vauthors = Lecroisey A, Keil B | title = Specificity of the collagenase from the insect ''Hypoderma lineatum'' |author1 = Lecroisey, A. |author2journal =Keil, B.European |journalJournal =of Eur. J. Biochem.Biochemistry |year = 1985 |volume = 152 | issue = 1 | pages = 123–130123–30 | date = October 1985 | pmid = 2995028 | doi = 10.1111/j.1432-1033.1985.tb09171.x }}</ref><ref>{{cite journal | vauthors = Lecroisey A, Gilles AM, De Wolf A, Keil B | title = Complete amino acid sequence of the collagenase from the insect ''Hypoderma lineatum'' |author1 journal = Lecroisey,The A.Journal |author2of =Gilles,Biological A.-M.Chemistry |author3 volume =De Wolf, A.262 |author4 issue =Keil, B.16 |journal pages = J. Biol. Chem.7546–51 |year = 1987 |volumedate = 262June |issue = 161987 |pages = 7546–7551 |pmid = 3034899 }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]
: [[Hydrolysis]] of proteins including native [[collagen]] at -Ala bond leaving an [[N-terminal]] (75%) and a [[C-terminal]] (25%) fragment
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