Classical complement pathway: Difference between revisions

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== Clinical significance ==

Because of its role in the innate immune system classical complement has been implicated in a number of pathogen related disorders. Complement is responsible for immune inflammatory response in adipose tissues which has been implicated in the development of [[obesity]].<ref name=":0">{{Cite journal|title = Alterations of the classic pathway of complement in adipose tissue of obesity and insulin resistance|url = http://ajpendo.physiology.org/content/292/5/E1433|journal = American Journal of Physiology. Endocrinology and Metabolism|date = 2007-05-01|issn = 0193-1849|pmid = 17244723|pages = E1433–E1440|volume = 292|issue = 5|doi = 10.1152/ajpendo.00664.2006|language = en|first = Jinhui|last = Zhang|first2 = Wendy|last2 = Wright|first3 = David A.|last3 = Bernlohr|first4 = Samuel W.|last4 = Cushman|first5 = Xiaoli|last5 = Chen}}</ref> Obesity in turn results in an abnormally high level of complement activation via production of the c1 component of the classical pathway, which can lead to tissue inflammation and eventually [[Metabolic syndrome|insulin resistance]], however the exact mechanisms that causes this is yet unknown.<ref name=":0"/>

Immunotherapies have been developed to detect and destroy cells infected by the HIV virus via classical complement activation.<ref>{{Cite journal|title = Synthetic immunotherapy induces HIV virus specific Th1 cytotoxic response and death of an HIV-1 infected human cell line through classic complement activation|journal = Virology Journal|date = 2013-04-04|volume = 10|issue = 1|doi = 10.1186/1743-422x-10-107|pmid = 23557359|pmc = 3626621|language = En|first = Olga|last = Pleguezuelos|first2 = Gregory A|last2 = Stoloff|first3 = Wilson|last3 = Caparrós-Wanderley|pages=107}}</ref> This process involves creating synthetic peptides that target conserved regions in HIV specific proteins and induce an antibody specific immune response through IgG antibodies. This is important for targeting the virus in its intracellular phase because the antibodies specific to the synthetic peptides can trigger the classical complement pathway and induce the death of HIV infected cells.