Automated tissue image analysis: Difference between revisions

Revision as of 06:17, 27 September 2019

Revision as of 21:47, 12 November 2019

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'''Automated tissue image analysis''' is a process by which computer-controlled [[automatic test equipment]] is used to evaluate [[tissue (biology)|tissue]] samples, using computations to derive quantitative measurements from an image to avoid subjective errors.

In a typical application, automated tissue image analysis could be used to measure the aggregate activity of [[cancer cell]]s in a [[biopsy]] of a [[cancer]]ous [[tumor]] taken from a patient. In [[breast cancer]] patients, for example, automated tissue image analysis may be used to test for high levels of [[proteins]] known to be present in more aggressive forms of breast cancers.

==Applications==

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{{cite journal

|title=A System for Automated Liver Tissue Image Analysis: Methods and Results

|author1=O'Gorman, Lawrence
|author2=Sanderson, Arthur C.
|author3=Preston, Kendall
|journal=IEEE Transactions on Biomedical Engineering

|date=September 1985

|volume=BME-32

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|issn=0018-9294

|doi=10.1109/TBME.1985.325587

|pmid=4054933

|pmid=4054933 |url=http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=4122137

}}</ref> or improve the prediction rate of recurrence of some cancers.<ref name="Teverovskiy_2004">

{{cite journalbook

|title=Improved prediction of prostate cancer recurrence based on an automated tissue image analysis system

|author=Teverovskiy, M.

|author2= Kumar, V.

|author3= Junshui Ma

|author4= Kotsianti, A.

|author5= Verbel, D.

|author6= Tabesh, A.

|author7= Ho-Yuen Pang

|author8= Vengrenyuk, Y.

|author9= Fogarasi, S.

|author10= Saidi, O.

|author11= ((Aureon Biosciences Corp., Yonkers, NY, USA))

|journal=Biomedical Imaging: Nano to Macro, 2004. IEEE International Symposium

|date=2004-04-18

|pages=257–260

|volume=1

|isbn=0-7803-8388-5

|doi=10.1109/ISBI.2004.1398523

|citeseerx=10.1.1.58.9929

|titlechapter=Improved prediction of prostate cancer recurrence based on an automated tissue image analysis system

|title=2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano (IEEE Cat No. 04EX821)

|volume=12

|pages=257–260

|year=2004

|authorlast1=Teverovskiy, |first1=M.

|last2=Kumar |first2=V.

|author3last3= Junshui Ma

|last4=Kotsianti |first4=A.

|last5=Verbel |first5=D.

|last6=Tabesh |first6=A.

|author7last7= Ho-Yuen Pang

|last8=Vengrenyuk |first8=Y.

|last9=Fogarasi |first9=S.

|last10=Saidi |first10=O.

}}</ref><ref>{{cite journal

|journal = IEEE Transactions on Medical Imaging

|volume = 26

|issue = 10

|date = October 2007

|doi = 10.1109/TMI.2007.898536

|pmid = 17948727

|issn = 0278-0062

|pages = 1366–1378

|title = Multifeature Prostate Cancer Diagnosis and Gleason Grading of Histological Images

|author1 = Ali Tabesh

|author2 = Mikhail Teverovskiy

|author3 = Ho-Yuen Pang

|author4 = Vinay P. Kumar

|author5 = David Verbel

|author6 = Angeliki Kotsianti

|author7 = Olivier Saidi

|url = http://claymore.rfmh.org/~atabesh/papers/tabesh_tmi07_final.pdf

|access-date = 2010-09-04

|archive-url = https://web.archive.org/web/20110727214729/http://claymore.rfmh.org/~atabesh/papers/tabesh_tmi07_final.pdf

|archive-date = 2011-07-27

|url-status = dead

}}</ref> As it is a digital system, suitable for networking, it also facilitates cooperative efforts between distant sites.<ref>

{{cite journal

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High-performance [[Charge-coupled device|CCD cameras]] are used for acquiring the digital images. Coupled with advanced [[fluorescence microscope|widefield microscope]]s and various [[algorithms]] for [[Deconvolution#Optics and other imaging|image restoration]], this approach can provide better results than [[confocal microscope|confocal techniques]] at comparable speeds and lower costs.<ref name="Phukpattaranont_2007">

{{cite journalbook

|year=2007

|volume=15

Line 83 ⟶ 85:

==Processes==

The [[United States of America|United States]] [[Food and Drug Administration]] classifies these systems as [[medical device]]s, under the general instrumentation category of [[automatic test equipment]].<ref>{{cite book|url=https://books.google.com/books?id=nEHLxh9wxZIC&pg=PA80&lpg=PA80&dq=%22FDA+automatic+test+equipment%22 |title=Testing Computer Systems for FDA/MHRA Compliance - David Stokes - Google Books |date= 2003-11-25|accessdate=2012-07-12|isbn=9780849321634|last1=Stokes |first1=David }}</ref>

ATIS have seven basic processes (sample preparation, image acquisition, image analysis, results reporting, data storage, network communication, and self-system diagnostics) and realization of these functions highly accurate hardware and well-integrated, complex, and expensive software.<ref>{{cite journal|doi=10.1016/j.aca.2005.11.083 |pmid=17723364 |title=Analytica Chimica Acta - Advances in cancer tissue microarray technology: Towards improved understanding and diagnostics | volume=564 |issue=1 |journal=Analytica Chimica Acta |pages=74–81|pmc=2583100|year=2006 |last1=Chen |first1=W. |last2=Foran |first2=D. J. }}</ref>

===Preparation===

Specimen preparation is critical for evaluating the tumor in the automated system. In the first part of the preparation process the biopsied tissue is cut to an appropriate size (typically 4&nbsp;mm), fixed in buffered [[formalin]], dehydrated in ethanol-[[xylene]], embedded in [[Paraffin wax|paraffin]], [[thin section]]ed typically to 4&nbsp;um slices, then mounted onto at least two [[barcode]]d slides (a [[scientific control|control]] and a test). Next the paraffin is removed from the tissue, the tissue is rehydrated, then [[staining|stained]]. Any inconsistency in these procedures from case to case may result in uncertainties in the outcome of the analysis. These potential and irreducible inconsistencies in analysis results motivated the development of Automated Tissue Image Systems.

===Acquisition===

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===Reporting===

The systems have the capability of presenting the resulting data in text and graphically, including on high definition monitors, to the system user. [[Computer printers]], as relatively low image resolution devices, are used mostly to present final [[pathology]] reports that could include text and graphics.{{Citation needed|date=August 2010}}

===Storage===

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Medical imaging industry standards includes the [[Picture Archiving and Communication Systems]] (PACS), of European origin, which are image and information management solutions in computer networks that allow hospitals and clinics to acquire, distribute and archive medical images and diagnostic reports across the enterprise. Another standard of European origin is the Data and Picture Archiving and Communication System (DPACS). Although medical images can be stored in various formats, a common format has been Digital Imaging and Communications in Medicine ([[DICOM]]).{{Citation needed|date=August 2010}}

== See also ==

* [[Histopathology]]