Kanamycin A: Difference between revisions

Revision as of 22:50, 12 December 2006

Revision as of 06:15, 15 December 2006

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==Pharmacology==

Kanamycin works by affecting 30S ribosomal subunit and causing a [[frame-shift]]. This means that instead of a [[codon]] CAT (for example in sequence CATG), a codon ATG is read by [[aminoacyil tRNA]] (aa-tRNA). Aminoacyil tRNA is consequently carrying a different [[amino acid]], because the [[anticodon]] on the aa-tRNA is different. The [[protein]] needed cannot be synthesised - a completely different protein has been synthesised or a protein similar to the one needed, but not folded correctly; it depends of the site and severness of the frame-shift.

A bacterium is destroyed becasuebecause it cannot produce any of its proteins correctly.

Because of over usage of antibiotics in every possible (even viral) disease as a precaution many bacteria have developed a resistance against kanamycin, and, consequently, it is not being used much anymore.