Mitochondrial translational release factor 1: Difference between revisions

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Revision as of 12:10, 17 December 2020

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{{Infobox_gene}}

'''Mitochondrial translational release factor 1''', also known as '''MTRF1''' is a human [[gene]].<ref name="pmid9838146">{{cite journal |vauthors=Zhang Y, Spremulli LL | title = Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor | journal = Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | volume = 1443 | issue = 1–2 | pages = 245–50 |date=November 1998 | pmid = 9838146 | doi = 10.1016/S0167-4781(98)00223-1 | url = | issn = }}</ref><ref name="pmid10773675">{{cite journal |vauthors=Hansen LL, Jørgensen R, Justesen J | title = Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1→q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32→q34.1 with radiation hybrid mapping | journal = Cytogenetics and Cell Genetics | volume = 88 | issue = 1–2 | pages = 91–2 | year = 2000 | pmid = 10773675 | doi = 10.1159/000015494 | url = | issn = }}</ref>

The [[protein]] encoded by this gene directs the termination of [[Translation (biology)|translation]] in response to the peptide chain [[Stop codon|termination codons]]. Initially thought to have a role in the termination of [[Mitochondrion|mitochondria]] protein synthesis. mtRF1 has been hypothesized to recognize non-standard stop codons AGA and AGG in vertebrates. Alternatively, based on detailed 3D modelling, it has been proposed to recognize stalled ribosomes in which a tRNA is still bound to the peptide chain, but in which the A-site of the ribosome is empty.