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==The hypothesis==
The hypothesis is that [[chromatin]]-DNA interactions are guided by combinations of histone modifications. While it is accepted that modifications (such as [[methylation]], [[acetylation]], [[ADP-ribosylation]], [[ubiquitination]], [[citrullination]], and [[phosphorylation]]) to [[histone]] tails alter chromatin structure, a complete understanding of the precise mechanisms by which these alterations to histone tails influence DNA-histone interactions remains elusive. However, some specific examples have been worked out in detail. For example, phosphorylation of [[serine]] residues 10 and 28 on [[histone H3]] is a marker for chromosomal condensation. Similarly, the combination of phosphorylation of [[serine]] residue 10 and acetylation of a [[lysine]] residue 14 on histone H3 is a tell-tale sign of active [[Transcription (genetics)|transcription]].
[[File:Histone modifications.png|thumb|center|640px|Schematic representation of histone modifications. Based on Rodriguez-Paredes and Esteller, Nature, 2011]]
===Modifications===
Well characterized modifications to histones include:<ref name="Strahl">{{cite journal |vauthors=Strahl B, Allis C |title=The language of covalent histone modifications |journal=Nature |volume=403 |issue=6765 |pages=41–5 |year=2000 |pmid=10638745 |doi=10.1038/47412|bibcode=2000Natur.403...41S }}</ref>
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