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KinaseMap3k1 (talk | contribs) Added in interaction with MAP3K1 and reference Tags: Visual edit Mobile edit Mobile web edit |
KinaseMap3k1 (talk | contribs) Added in phosphorylation and ubiquitination Tags: Visual edit Mobile edit Mobile web edit |
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== Function ==
This gene was identified by the rapid tyrosine-phosphorylation of its product in response to cytokine stimulation. The encoded protein contains an SH3 ___domain and the immunoreceptor tyrosine-based activation motif (ITAM). This protein associates with JAK3 and JAK2 kinases via its ITAM region, and is phosphorylated by the JAK kinases upon cytokine stimulation, which suggests the function of this protein is as an adaptor molecule involved in the downstream signaling of cytokine receptors. HGS/HRS (hepatocyte growth factor-regulated tyrosine kinase substrate) has been found to bind and counteract the function of this protein.<ref name="entrez" /> STAM contains multiple amino acid sites that are phosphorylated and ubiquitinated.<ref>{{Cite web|title=STAM1 (human)|url=https://www.phosphosite.org/proteinAction.action?id=6864&showAllSites=true|access-date=2020-10-31|website=www.phosphosite.org}}</ref>
== Interactions ==
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