Glycan array: Difference between revisions

Revision as of 11:59, 18 November 2020

Revision as of 23:34, 20 December 2020

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==Applications==

The glycan array technology has been and still is applied to study the specificity of [[host-pathogen interactions]].

<ref name="Glycan arrays as tools for infectious disease research">{{cite journal|vauthors=Geissner A, Anish C, Seeberger PH|title=Glycan arrays as tools for infectious disease research|journal=Curr Opin Chem Biol|date=Feb 2014|volume=18|pages=38–45|doi=10.1016/j.cbpa.2013.11.013|pmid=24534751|pmc=}}</ref>

Early on, glycan arrays were proven useful in determining the specificity of the [[Hemagglutinin (influenza)]] of the [[Influenza A virus]] binding to the host and distinguishing across different strains of flu (including avian from mammalian). This was shown with CFG arrays <ref name="Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus">{{cite journal|vauthors=Stevens J, Blixt O, Tumpey TM, Taubenberger JK, Paulson JC, Wilson IA|title=Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus|journal=Science|date=Apr 2006|volume=312|issue=5772|pages=404–410|doi=10.1126/science.1124513|pmid=16543414|bibcode=2006Sci...312..404S|doi-access=free}}</ref> as well as customised arrays.<ref name="Receptor-binding specificity of pandemic influenza A (H1N1) 2009 virus determined by carbohydrate microarray">{{cite journal|vauthors=Childs RA, Palma AS, Wharton S, Matrosovich T, Liu Y, Chai W, Campanero-Rhodes MA, Zhang Y, Eickmann M, Kiso M, Hay A, Matrosovich M, Feizi T|title=Receptor-binding specificity of pandemic influenza A (H1N1) 2009 virus determined by carbohydrate microarray|journal=Nat Biotechnol|date=Sep 2009 |volume=27|issue=9|pages=797–799|doi=10.1038/nbt0909-797|pmid=19741625|pmc=3771066}}</ref>