Nel settembre 1854 la scuola si trasferì in una nuova sede, all'angolo fra Broad Street e Green Street. Nel settembre 1900 avvenne un ulteriore trasloco, in un edificio più grande e moderno fra Broad Street, Green Street, Fifteenth Street, e Brandywine Street. Infine, nel 1939, la ''Central'' si trasferì nell'attuale sede sulle Ogontz e Olney Avenues. L'edificio precedente è diventato la sede della [[Benjamin Franklin High School]].
AfterDopo 139 yearsanni of existence as an all-male publiccome highscuola schoolmaschile, Centrall'sesclusione all-maledelle policyragazze wasfu challengedcontestata byda Susan Vorchheimer,who wished to be admitted to Central. On August 7,nel 1975, [[United States District Court for the Eastern District of Pennsylvania|U.S. District Court]] Judge Clarence C. Newcomer ruled that Central must admit academically qualified girls starting in the fall term of 1975. The decision was appealed, and the [[United States Court of Appeals for the Third Circuit|Third Circuit Court]] ruled that Central had the right to retain its present status.<ref>{{cite court |litigants=Vorchheimer v. School District of Philadelphia |vol=532 F.2d 880 |reporter= |opinion= |pinpoint= |court=[[United States Court of Appeals for the Third Circuit|Third Circuit Court]] |date=1976 |url= |accessdate=3 Junegiugno 2015 |quote=}}</ref>. TheIl casecaso eventuallyarrivò reachedfino thealla [[SupremeCorte Courtsuprema ofdegli theStati United States|U.S. Supreme CourtUniti]] that,che on April 19,nel 1977,upheldconfermò the Third Circuit Courtl'sesclusione verdictdelle by a 4 to 4 vote with one abstention. That Supreme Court case was called ''[[Vorchheimer v. School Dist. of Philadelphia]]''.studentesse<ref>{{cite court |litigants= Vorchheimer v. School District of Philadelphia|vol=430 U.S. 703, 97 S.Ct. 1671, 51 L.Ed.2d 750 |reporter= |opinion= |pinpoint= |court=Supreme Court of the United States |date=1977 |url= |accessdate=3 Junegiugno 2015 |quote=}}</ref><ref>https://www.oyez.org/cases/1976/76-37</ref>.
In August 1983, Judge William M. Marutani of the [[Philadelphia County, Pennsylvania|Philadelphia County]] [[Pennsylvania Courts of Common Pleas|Court of Common Pleas]], ruled that the single-sex admission policy was unconstitutional. The Board of Education voted not to appeal the legal decision, thereby admitting girls to Central High School. In September 1983, the first six girls, all seniors, were admitted.{{citation needed|date = March 2017}}
