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== History ==
In 1978, [[Walter Gilbert]] published "Why Genes in Pieces" which first began to explore the idea that the gene is a mosaic—that each full [[nucleic acid]] strand is not coded continuously but is interrupted by "silent" non-coding regions. This was the first indication that there needed to be a distinction between the parts of the genome that code for protein, now called coding regions, and those that do not.<ref>{{cite journal | vauthors = Gilbert W | title = Why genes in pieces? | journal = Nature | volume = 271 | issue = 5645 | pages = 501 | date = February 1978 | pmid = 622185 | doi = 10.1038/271501a0 | bibcode = 1978Natur.271..501G | s2cid = 4216649 | doi-access = free }}</ref>
== Composition ==
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