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DGRs are beneficial to the evolution and survival of their host. A large fraction of [[Faecalibacterium prausnitzii]] phages contain DGRs that are believed to have a role in phage adaptability to the digestive system, as patients with inflammatory bowel disease (IBD), have more phages, but less F.prausnitzii in their stool samples compared to healthy individuals, suggesting that these phages activate during the illness, and that they may trigger F.prausnitzii depletion.<ref>{{Cite journal|last=Cornuault|first=Jeffrey K.|last2=Petit|first2=Marie-Agnès|last3=Mariadassou|first3=Mahendra|last4=Benevides|first4=Leandro|last5=Moncaut|first5=Elisabeth|last6=Langella|first6=Philippe|last7=Sokol|first7=Harry|last8=De Paepe|first8=Marianne|date=2018-04-03|title=Phages infecting Faecalibacterium prausnitzii belong to novel viral genera that help to decipher intestinal viromes|url=http://dx.doi.org/10.1186/s40168-018-0452-1|journal=Microbiome|volume=6|issue=1|doi=10.1186/s40168-018-0452-1|issn=2049-2618|doi-access=free}}</ref> Several tools have been implemented to identify DGRs, such as DiGReF,<ref>{{Cite journal|last=Schillinger|first=Thomas|last2=Lisfi|first2=Mohamed|last3=Chi|first3=Jingyun|last4=Cullum|first4=John|last5=Zingler|first5=Nora|date=2012|title=Analysis of a comprehensive dataset of diversity generating retroelements generated by the program DiGReF|url=http://dx.doi.org/10.1186/1471-2164-13-430|journal=BMC Genomics|volume=13|issue=1|pages=430|doi=10.1186/1471-2164-13-430|issn=1471-2164|doi-access=free}}</ref> DGRscan,<ref>{{Cite journal|last=Ye|first=Yuzhen|date=2014-08-15|title=Identification of Diversity-Generating Retroelements in Human Microbiomes|url=http://dx.doi.org/10.3390/ijms150814234|journal=International Journal of Molecular Sciences|volume=15|issue=8|pages=14234–14246|doi=10.3390/ijms150814234|issn=1422-0067|doi-access=free}}</ref> MetaCSST,<ref>{{Cite journal|last=Yan|first=Fazhe|last2=Yu|first2=Xuelin|last3=Duan|first3=Zhongqu|last4=Lu|first4=Jinyuan|last5=Jia|first5=Ben|last6=Qiao|first6=Yuyang|last7=Sun|first7=Chen|last8=Wei|first8=Chaochun|date=2019-07-19|title=Discovery and characterization of the evolution, variation and functions of diversity-generating retroelements using thousands of genomes and metagenomes|url=http://dx.doi.org/10.1186/s12864-019-5951-3|journal=BMC Genomics|volume=20|issue=1|doi=10.1186/s12864-019-5951-3|issn=1471-2164|doi-access=free}}</ref> and myDGR<ref>{{Cite journal|last=Sharifi|first=Fatemeh|last2=Ye|first2=Yuzhen|date=2019-05-03|title=MyDGR: a server for identification and characterization of diversity-generating retroelements|url=http://dx.doi.org/10.1093/nar/gkz329|journal=Nucleic Acids Research|volume=47|issue=W1|pages=W289–W294|doi=10.1093/nar/gkz329|issn=0305-1048|doi-access=free}}</ref>
==See also==
* [[Retron]]
== References ==
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