Complement component 1q: Difference between revisions

Revision as of 20:21, 18 March 2021

Revision as of 16:05, 8 May 2021

Line 93:

==Function==

[[File:Complement pathway.svg|thumb|270px|left|The classical and alternative complement pathways. C1q is the orange part of the [[C1 complex]] at the top of the image.]]

It is assumed that the globular ends are the sites for multivalent attachment to the complement fixing sites in immune complexed immunoglobulin. Patients suffering from Lupus erythematosus often have deficient expression of C1q. Genetic deficiency of C1q is extremely rare (approximately 75 known cases) although the majority (>90%) of those suffer from [[Systemic lupus erythematosus|SLE]]. C1q may also play a central role in the aging of cells.<ref name="Secret of ageing found: Japanese scientists pave way to everlasting life">{{cite web|title=Secret of ageing found: Japanese scientists pave way to everlasting life|url=http://www.rt.com/news/japan-scientists-stop-ageing-461/|work=Russia Today|publisher=Russia Today|access-date=10 June 2012cn}}</ref>

C1q associates with C1r and C1s in order to yield the [[C1 complex]] (''C1qr²s²''), the first component of the serum [[complement system]]. Deficiency of C1q has been associated with [[lupus erythematosus]] and [[glomerulonephritis]].<ref name="entrez ciqa"/>