SNP array: Difference between revisions

Revision as of 04:06, 16 January 2007

Revision as of 19:51, 22 January 2007

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AIn [[molecular biology]] and [[bioinformatics]], a '''SNP array''' is a type of [[DNA microarray]] which is used to detect [[polymorphisms]] within a population. A [[single nucleotide polymorphism]] (SNP), a variation at a single site in DNA, is the most frequent variation in the genome, there are about 5-10 million SNPs in the human genome. As SNPs are highly conserved throughout evolution and within population, the map of SNPs serves as an excellent genotypic marker for research.

==Principles==

The basic principles of SNP-array is the same as the [[DNA microarray]] which is the convergence of [[DNA hybridization]], fluorescence microscopy and solid surface DNA capture. The three mandatory components of the SNP arrays are

# the array that contains immobilized nucleic acid sequences or target;

# one or more labeled probes;