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Line 4: ==History== Ten years after [[James Watson]] and [[Francis Crick]] published their model of the DNA double helix,<ref name="Watson">{{cite journal \|title=Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid\|vauthors=Watson JD, Crick FH \|journal=Nature\|year=1953\|volume=171\|issue=4356\|pages=737–738\|doi=10.1038/171737a0\|pmid=13054692\|bibcode=1953Natur.171..737W\|s2cid=4253007 }}</ref> [[Karst Hoogsteen]] reported <ref>{{cite journal \|title=The crystal and molecular structure of a hydrogen-bonded complex between 1-methylthymine and 9-methyladenine\|author=Hoogsteen K\|journal=Acta Crystallographica\|year=1963\|volume=16\|issue=9\|pages=907–916\|doi=10.1107/S0365110X63002437\|doi-access=free}}</ref> a crystal structure of a complex in which analogues of A and T formed a base pair that had a different geometry from that described by Watson and Crick. Similarly, an alternative base-pairing geometry can occur for G•C pairs. Hoogsteen pointed out that if the alternative hydrogen-bonding patterns were present in DNA, then the double helix would have to assume a quite different shape. Hoogsteen base pairs are observed in alternative structures such as the four-stranded [[G-quadruplex]] structures that form in DNA and RNA. ==Chemical properties==

Hoogsteen base pair: Difference between revisions