Azide-alkyne Huisgen cycloaddition: Difference between revisions

Revision as of 12:33, 9 August 2021

Revision as of 09:00, 10 August 2021

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In the uncatalysed reaction the alkyne remains a poor electrophile. Thus high energy barriers lead to slow reaction rates.<ref>{{cite journal |author1=V. D. Bock |author2=H. Hiemstra |author3=J. H. van Maarseveen | title = CuI-Catalyzed Alkyne–Azide "Click" Cycloadditions from a Mechanistic and Synthetic Perspective | year = 2006 | journal = [[European Journal of Organic Chemistry]] | pages = 51–68 | doi = 10.1002/ejoc.200500483 | volume = 2006}}</ref>

[[File:CuAAC mechanismCuAAC_mech.png|center|450px600px|Mechanism for Copper-catalysed click chemistry.]]

===Ligand assistance===