Talk:Alprazolam: Difference between revisions

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There are also no sources to back up the claim made in the recreational use area of the page regarding increased potency.
 
Also, numerous sources have verified that the bioavalability of alprazolam is NOTnot significantly increased in a statistically meaningful way by the consumption of grapefruit juice, however, the decreased metabolic effects ofcaused by grapefruit juice and/or other citrus juices can cause a gradualan increase in blood serum levels and can increase the longevity of the elimination half-life of alprazolam, possibly to toxic levels, although, is generally unlikely unless copious amounts are consumed; however, toxicity resulting from consumption of grapefruit juice or other citrus fruits is unlikely while administering aplrazolam; this is often more characteristic of medications that interact with grapefruit juice (i.e. opioids, benzodiazepines) that have a lower binding percentage to blood plasma proteins since alprazolam is approximately eighty percent bound in human plasma therefore, it does not have much more potential to increase to cause lethal toxicity. (Refer to Clinical Pharmacology at RXList.com)