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→Techniques: Fixed entangled description after edit by 134.184.84.193 on 2019-09-25 |
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* Important information on protein synthesis, [[Ligand (biochemistry)|ligand binding]] and RNA interaction can be obtained using this novel technique at medium resolutions of 7.5 to 25Å.<ref>{{cite journal |vauthors=Arias-Palomo E, Recuero-Checa MA, Bustelo XR, Llorca O |title=3D structure of Syk kinase determined by single-particle electron microscopy |journal=Biochim. Biophys. Acta |volume=1774 |issue=12 |pages=1493–9 |date=December 2007 |pmid=18021750 |pmc=2186377 |doi=10.1016/j.bbapap.2007.10.008 }}</ref>
* ''[[Methanococcus maripaludis]]'' chaperonin,<ref>Japanese Protein databank http://www.pdbj.org/emnavi/emnavi_movie.php?id=5137</ref> reconstructed to 0.43 nanometer resolution.<ref name="Zhang J">{{Cite journal |vauthors=Zhang J, Baker ML, Schröder GF, etal |title=Mechanism of folding chamber closure in a group II chaperonin |journal=Nature |volume=463 |issue=7279 |pages=379–83 |date=January 2010 |pmid=20090755 |pmc=2834796 |doi=10.1038/nature08701|bibcode=2010Natur.463..379Z }}</ref> This bacterial protein complex is a machine for folding other proteins, which get trapped within the shell.
* [[Fatty acid synthase]]<ref>Japanese Protein databank http://www.pdbj.org/emnavi/emnavi_movie.php?id=1623</ref> from yeast at 0.59 nanometer resolution.<ref name="Gipson">{{Cite journal|vauthors=Gipson P, Mills DJ, Wouts R, Grininger M, Vonck J, Kühlbrandt W |title=Direct structural insight into the substrate-shuttling mechanism of yeast fatty acid synthase by electron cryomicroscopy |journal=Proceedings of the National Academy of Sciences of the United States of America |volume=107 |issue=20 |pages=9164–9 |date=May 2010 |pmid=20231485 |pmc=2889056 |doi=10.1073/pnas.0913547107|bibcode=2010PNAS..107.9164G |doi-access=free }}</ref> This huge enzyme complex is responsible for building the long chain fatty acids essential for cellular life.
* A 0.33 nanometer reconstruction of [[Golden shiner virus|Aquareovirus]].<ref>Japanese Protein databank http://www.pdbj.org/emnavi/emnavi_movie.php?id=5160</ref><ref name="Zhang X">{{Cite journal|vauthors=Zhang X, Jin L, Fang Q, Hui WH, Zhou ZH |title=3.3 A cryo-EM structure of a nonenveloped virus reveals a priming mechanism for cell entry |journal=Cell |volume=141 |issue=3 |pages=472–82 |date=April 2010 |pmid=20398923 |doi=10.1016/j.cell.2010.03.041 |pmc=3422562}}</ref> These viruses infect fish and other aquatic animals. The reconstruction has high enough resolution to have amino acid side chain densities easily visible.
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