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Dstl was formed from the July 2001 split of the [[Defence Evaluation and Research Agency]] (DERA). Dstl was established to carry out and retain the science and technology work that is best done within government,<ref>{{cite web |url=https://www.dstl.gov.uk/downloads/framework.pdf |title=Archived copy |access-date=16 February 2014 |archive-url=https://web.archive.org/web/20140222100131/https://www.dstl.gov.uk/downloads/framework.pdf |archive-date=22 February 2014 |url-status=dead}}</ref> while work that could be done by industry (forming the majority of DERA's activities) was transferred to [[Qinetiq]], a government-owned company that was later floated on the stock exchange.
Dstl absorbed the Home Office's Centre for Applied Science and Technology (CAST) in April 2018,<ref name=":1">{{Cite web|date=24 April 2018|title=Centre for Applied Science and Technology (CAST) becomes part of Dstl|url=https://www.gov.uk/government/news/centre-for-applied-science-and-technology-cast-becomes-part-of-dstl|url-status=live|access-date=2021-12-24|website=GOV.UK|language=en|archive-url=https://web.archive.org/web/20180424162916/https://www.gov.uk/government/news/centre-for-applied-science-and-technology-cast-becomes-part-of-dstl |archive-date=24 April 2018 }}</ref> taking on CAST's role<ref>{{cite book |url=https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/530164/intro-to-cast-june2016.pdf |title=Home Office Science: Centre for Applied Science and Technology: An Introduction |publisher=Home Office |year=2016 |isbn=978-1-78655-083-5 |___location=United Kingdom |pages=3–4}}</ref> to apply science and technology to support the Home Office's operations and frontline delivery, provide evidence to support policy, and perform certain regulatory functions.
Dstl was a [[trading fund]] of the MOD from its formation until 2016, when it became an [[executive agency]] of the MOD.
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