Add: doi-access. Removed proxy/dead URL that duplicated identifier. | Use this bot. Report bugs. | Suggested by Headbomb | Linked from Wikipedia:WikiProject_Academic_Journals/Journals_cited_by_Wikipedia/Sandbox | #UCB_webform_linked 837/1125
In [[bioinformatics]] and [[evolutionary biology]], a '''substitution matrix''' either describes the ratefrequency at which a character in a [[Nucleic acid sequence|nucleotide sequence]] or a [[Protein primary structure|protein sequence]] changes to other character states over evolutionary time. oritThe describesinformation is often in the form of log odds of finding two specific character states aligned and depends on the assumed number of evolutionary changes or sequence dissimilarity between compared sequences. It is an application of a [[stochastic matrix]]. Substitution matrices are usually seen in the context of [[amino acid]] or [[DNA]] [[sequence alignment]]s, where thethey are used to calculate similarity scores between the aligned sequences depends<ref onname="Zvelebil">{{cite theirbook divergence|last1=Zvelebil time|first1=Marketa andJ. the|title=Understanding substitutionbioinformatics rates|date=2008 as|publisher=Garland representedScience in|___location=New theYork matrix|isbn=978-0-8153-4024-9. |pages=117-127, 747}}</ref>.
