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Modifications had been developed enabling the split and pool synthesis to produce known compounds in larger quantities than the content of a bead of solid support and retain the high efficiency of the original method.
As published by Moran et al.<ref>E. J. Moran, S. Sarshar, J. F. Cargill, M. Shahbaz, A Lio, A. M. M. Mjalli, R. W. Armstrong J. Am. Chem. Soc. 1995, 117, 10787.</ref> and Nicolau et al.<ref>K. C. Nicolaou, X –Y. Xiao, Z. Parandoosh, A. Senyei, M. P. Nova Angew. Chem. Int. Ed. Engl. 1995, 36, 2289.</ref> the resin normally used in the solid phase synthesis was enclosed into permeable capsules including a radiofrequency label recording the BBs in order of their coupling. Both manual and automatic machine was constructed to sort the capsules into the appropriate reaction vessels.
A different kind of labeled macroscopic solid support unit was introduced by Xiao et al.<ref>X.-Y. Xiao, C. Zhao, H. Potash, M. P. Nova Angew. Chem. Int. Ed. Engl., 1997, 36, 780.</ref> The supports are 1x1 cm polystyrene grafted square plates. The medium carrying the code is a 3x3 mm ceramic plate in the center of the synthesis support The code is etched into the ceramic support by a
====String synthesis====
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