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'''nQuery is a clinical trial design platform''' used for the design and monitoring of adaptive, group sequential and fixed sample size trials. It is most commonly used by Biostatisticiansbiostatisticians to calculate [[Sample size determination|Samplesample size]] and [[Statisticalstatistical power]] for [[Adaptive clinical trial|adaptive clinical trial design.]] nQuery is a proprietary software developed and distributed by [[Statsols]]. nQuery includes calculations for 1000+ sample sizesizes and power scenarios.
==nQuery history==
[[Janet D. Elashoff|Janet Dixon Elashoff]] is a now-retired American statistician and daughter of the mathematician and statistician, [[Wilfrid Dixon|Wilfrid Joseph Dixon]], creator of BMDP. J. Elashoff is also the retired Director of the Division of Biostatistics, [[Cedars-Sinai Medical Center]]. While at [[University of California, Los Angeles|UCLA]] and Cedars-Sinai during the 1990s, she wrote the program nQuery Sample Size Software (then known asnamed nQuery Advisor back then). This software quickly became widely used to estimate the sample size requirements for pharmaceutical testingtrials. and sheShe joined the company, Statistical Solutions LLC, to commercialize it.<ref name=cherfriis>{{citation|title=Introductory Biostatistics for the Health Sciences: Modern Applications Including Bootstrap|series=Wiley series in probability and statistics|first1=Michael R.|last1=Chernick|first2=Robert H.|last2=Friis|publisher=John Wiley & Sons|year=2003|isbn=9780471458654|page=360|url=https://books.google.com/books?id=QRwuz6yA97oC&pg=PA360}}</ref>
==nQuery featured in scientific journals ==
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ThereAs areof overMay 62022,000 scientificthere studiesare that8,250 featurepublished nQuery.scientific studies, Thesewhich are available to the public forthrough educationalGoogle andScholar, researchthat purposes.<ref>{{Citefeature web|url=https://scholar.googlenQuery.com/scholar?start=0&q=%22nquery%22|title=Google Scholar}}</ref> The USU.S. [[National Institutes of Health]] Library lists over 895 published studies that usedutilized nQuery for sample size calculation forduring clinical trial design. These are freely available to the public to review.<ref>{{Cite web|url=https://www.ncbi.nlm.nih.gov/pmc/?term=nquery|title=Nquery - PMC - NCBI}}</ref>
== Frequentist and Bayesian statistics ==
== Adaptive clinical trial design ==
nQuery is used for [[Adaptive clinical trial|Adaptiveadaptive clinical trial design.]] Trials with an adaptive design are often reported to be often more efficient, informative, and ethical than trials with a traditional fixed design since they often make better use ofconserve resources such as time and money, and mightmost of time, require fewer participants.<ref>{{Cite journal | doi=10.1186/s12916-018-1017-7| pmid=29490655| pmc=5830330| title=Adaptive designs in clinical trials: Why use them, and how to run and report them| year=2018| last1=Pallmann| first1=Philip| last2=Bedding| first2=Alun W.| last3=Choodari-Oskooei| first3=Babak| last4=Dimairo| first4=Munyaradzi| last5=Flight| first5=Laura| last6=Hampson| first6=Lisa V.| last7=Holmes| first7=Jane| last8=Mander| first8=Adrian P.| last9=Odondi| first9=Lang'o| last10=Sydes| first10=Matthew R.| last11=Villar| first11=Sofía S.| last12=Wason| first12=James M. S.| last13=Weir| first13=Christopher J.| last14=Wheeler| first14=Graham M.| last15=Yap| first15=Christina| last16=Jaki| first16=Thomas| journal=BMC Medicine| volume=16| issue=1| pages=29}}</ref>
== nQuery acquired by Insightful Science ==
In June 2020, nQuery was acquired by Insightful Science.<ref>{{cite web| url = https://www.prnewswire.com/news-releases/insightful-science-acquires-nquery-builds-on-portfolio-of-category-leading-scientific-software-solutions-301068141.html| title = Insightful Science Acquires nQuery, Builds on Portfolio of Category-Leading Scientific Software Solutions}} </ref>Products within the Insightful Science portfolio include GraphPad Prism, Geneious DNA data analysis, Geneious Prime and Geneious Biologics, SnapGene and SnapGene Server, and the contract research organization (CRO) Cytapex Bioinformatics.
==References==
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