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===Split and pool synthesis in solution===
Han et al. described a method that made it possible to keep the advantages of both the high efficiency of S&P synthesis and that of a homogeneous media in the chemical reactions.<ref>H. Han, M. M. Wolfe, S. Brenner, K. D. Janda Liquid-phase combinatorial synthesis Proc Natl Acad Sci USA 1995, 92:6419. https://doi.org/10.1073/pnas.92.14.6419</ref> In their method polyethyleneglycol (PEG) was used as soluble support in S&P synthesis of peptide libraries.
MeO-CH<sub>2</sub>-CH<sub>2</sub>-O-(CH<sub>2</sub>-CH<sub>2</sub>-O)n-CH<sub>2</sub>-CH<sub>2</sub>-OH
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