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==Plot==
A plane crashes near a town called Ruby after its cargo escapes. The cargo survives the crash and attacks Ruby citizens, starting with a couple named Lisa and Roberta, camping in the woods.
{{long plot|date=September 2021}}
The crew of a plane gets nervous when the cargo starts making noises and shifting. When one of the crew opens the crate, the pilot hears screams from the back. Something attacks him, causing the plane to crash near a town called Ruby. The cargo survives the crash and begins attacking Ruby citizens, starting with a couple named Lisa and Roberta, camping in the woods.
At a swimming hole the next day, John Cooper, his girlfriend Kristin, his best friend Tommy, and Tommy's girlfriend Theresa find aLisa's pet [[Burmese python]] that belonged to Lisa. Deputy Greg shows uparrives, mentioning that Lisa is missing, and takes the snake. Lisa's body is found, appearing to have been corroded by acids. Greg suspects John, since he works at a plant that uses acids. Greg is also Kristin's ex-fiancé, with her having left him when her first love came back to town.
Scientist Anton Rudolph is talkingmeets with [[NSA]] Special Agent Parker,. explaining that theThe cargo is an abnormally large [[reticulated python]] that has been genetically engineered in [[Southeast Asia]], blending several species. In the words of Dr. Rudolph, it is, "''a perfect killing machine. A 129-foot all-terrain vehicle, capable of speeds exceeding 50 miles an hour, with skin that can deflect an antitank round, enhanced night vision, and a voracious appetite for human flesh''". The NSA team plans an assault against the snake, hoping to kill it discreetly before it eats more people.
The snake kills a real estate agent and the agent's client., It leavesleaving behind the client and Roberta's bodybodies. John arrives as the snake leaves, furthering suspicion against him. The sheriff shuts down his brother Brian's plant, furthering the tensions between him and Brian. As John leaves the plant, he runs into Greg's car and his bike is damaged. They end up in a fistfight, mostly over Kristin, though they ultimately reconcile. When the body of the real estate agent is found with the same acid damage, the sheriff orders John arrested. Kristin yells at Greg when they come to arrest John, but he says that he does not think John is the killer.
The NSA team and RudolphAnton arrive, telling the sheriff a story about a psychotic rogue operative who is committing the murders. He does not believe them, but goes back to the office and frees John. Kristin, Tommy, Theresa, and he plan to go on a trip the next morning.
The NSA set up base at a water treatment center. They use radar to find where the snake is likely to be, then have the police set up a perimeter to keep people out of the zone. Believing the snake to be sleeping, the team wastes most of its ammunition on the snake's shed skin. Agent Parker realizes the snake used its skin as a decoy. The snake kills the team, the sole survivor being RudolphAnton who keeps himself standing motionless in front of the creature.
Theresa's morning shower is interrupted by the snake. Though she escapes, the snake eats Tommy. Theresa drives away, but the snake follows. It gets in front of her and disables the truck. Theresa hides in a crevice.
When Tommy and Theresa do not pick them uparrive, John and Kristin go looking for them, finding the wrecked truck. Theresa tries to warnwarning them as the snake comes to attackapproaches, but they cannot hear her. John and Kristin escape using Tommy and Theresa's bikes from the truck. They make it to the water treatment center, where Theresa later joins them, and find RudolphAnton in shock. The group realizes that they must do something about the snake or it will get to the town. They call Greg on the radio and fill him in on a plan they have devised.
They lure the snake into the water treatment plant by having it chase John through a shaft, while they set a bomb near the entrance. Kristin drops a line down another shaft for John to escape. They pull John out and the python is unable to climb up the shaft. Trapped in the tunnel, the python returns to the doorway entrance. The group returns to the entrance to trigger the bomb, but it does not detonate. RudolphAnton runs back in to reset it. While RudolphAnton resetsdetonates the charges, he iswhile confronted by the snake, butsacrificing is able to succeed in his taskhimself. The charges go off, killing Rudolph; whileWhile the other four are celebrating their success, the python emerges unscathed.
The group flees in Greg's police car, planning to penetrate the snake's hide by luring the snake into a vat of [[acid]] at John's plating plant. They are able to push the snake's underbelly into one of the vats, causing the snake to be killed by the acid.
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