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[[File:Plasmablast, Wright stain.png|thumb|Plasmablast, [[Wright stain]].]]
'''Lymphoid neoplasms with plasmablastic differentiation''' were classified by the [[World Health Organization]], 2017 as a sub-grouping of several distinct but rare lymphomas in which the malignant cells are [[B-cell]] lymphocytes that have become plasmablasts, i.e. [[Plasma cell#Immature plasma cells|immature plasma cells]].<ref name="pmid31725418">{{cite journal | vauthors = Chen BJ, Chuang SS | title = Lymphoid Neoplasms With Plasmablastic Differentiation: A Comprehensive Review and Diagnostic Approaches | journal = Advances in Anatomic Pathology | volume = 27 | issue = 2 | pages = 61–74 | date = March 2020 | pmid = 31725418 | doi = 10.1097/PAP.0000000000000253 | doi-access = free }}</ref> Normally, [[B-cell]]s take up foreign antigens, move to the [[germinal center]]s of secondary [[lymphoid organs]] such the [[spleen]] and [[lymph node]]s, and at these sites are stimulated by [[T-cell]] lymphocytes to [[Cellular differentiation|differentiate]] (i.e. change their cell type) into plasmablasts and thereafter mature plasma cells. Plasmablasts, and to a greater extent, plasma cells make and secrete [[antibodies]] that bind the antigens to which their predecessor B-cells were previously exposed (see [[Plasma cell#differentiation|plasma cell differentiation]]). Antibodies function, in part, to neutralize harmful bacteria and viruses by binding antigens that are exposed on their surfaces. Due to their malignant nature, however, the plasmablasts in lymphoid neoplasms with plasmablastic differentiation do not mature into plasma cells or form antibodies but rather uncontrollably proliferate in and damage various tissues and organs. The individual lymphomas in this sub-group of [[malignancies]] have heterogeneous clinical, morphological, and gene findings that often overlap with other members of the sub-group. In consequence, correctly diagnosing these lymphomas has been challenging.<ref name="pmid31360094">{{cite journal | vauthors = Lopez A, Abrisqueta P | title = Plasmablastic lymphoma: current perspectives | journal = Blood and Lymphatic Cancer: Targets and Therapy | volume = 8 | pages = 63–70 | date = 2018 | pmid = 31360094 | pmc = 6467349 | doi = 10.2147/BLCTT.S142814 }}</ref> Nonetheless, it is particularly important to diagnose them correctly because they often have very different prognoses and treatments.<ref name="pmid31725418"/> The lymphoid neoplasms with plasmacytic differentiation are:<ref name="pmid31725418"/><ref name="pmid31360094"/>
* '''1)''' [[Plasmablastic lymphoma]]: The most common of these lymphoid neoplasms.
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