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Following a review and consultation process initiated by MOD's Chief Scientific Advisor (CSA), it became responsible for the formulation and commission of MOD's non-nuclear research programme from 1 April 2010, under the responsibility of the Dstl Programme Office.<ref>{{cite web |url= https://publications.parliament.uk/pa/cm201011/cmselect/cmdfence/writev/761/nns45.htm |title=The Strategic Defence and Security Review and The National Security Strategy |work=publications.parliament.uk |year=2011 |access-date=12 June 2011}}</ref><ref>{{cite press release |date=19 March 2010 |title=Dstl to become the key focus of science and technology within MOD |url=http://www.mod.uk/DefenceInternet/DefenceNews/DefencePolicyAndBusiness/DstlToBecomeTheKeyFocusOfScienceAndTechnologyWithinMod.htm |publisher=[[Ministry of Defence (United Kingdom)|Ministry of Defence]] |archive-url=http://webarchive.nationalarchives.gov.uk/20121026065214/http://www.mod.uk/DefenceInternet/DefenceNews/DefencePolicyAndBusiness/DstlToBecomeTheKeyFocusOfScienceAndTechnologyWithinMod.htm |archive-date=26 October 2012 |access-date=16 February 2014}}</ref> Within the Programme Office were 16 domains<ref>[http://webarchive.nationalarchives.gov.uk/20121106233608/http://www.bis.gov.uk/assets/ukspaceagency/docs/space%20science/aurora/knowledge-exchange-april-2011/gibson-dstl-presentation.pdf National Archives (UK)]</ref> with some established as Science and Technology Centres, including Armour and Protection, Cyber and Influence, Counter Terrorism, and CBR (Chemical, Biological and Radiological).<ref>{{Cite web|url=https://www.dstl.gov.uk/scienceandtechnologycentres|title=Science and Technology Centres {{!}} dstl {{!}} Defence Science and Technology Laboratory|website=dstl.gov.uk|publisher=Ministry of Defence|archive-url=https://web.archive.org/web/20140222100139/https://www.dstl.gov.uk/scienceandtechnologycentres|archive-date=22 February 2014}}</ref> These centres fund research via the Centre for Defence Enterprise,<ref>{{cite web |url=http://www.science.mod.uk/engagement/enterprise.aspx |title=Centre for Defence Enterprise |publisher=[[Ministry of Defence (United Kingdom)|Ministry of Defence]] |access-date=16 February 2014}}</ref> also part of the Programme Office.<ref>{{cite web |url=http://www.science.mod.uk/engagement/dstl.aspx |title=The Defence Science and Technology Laboratory (Dstl) |publisher=[[Ministry of Defence (United Kingdom)|Ministry of Defence]] |access-date=16 February 2014}}</ref>
A subsequent MOD CSA-led review in 2015 into MOD's science and technology capability recommended that the commissioning of science and technology should be independent of the delivery.<ref>{{cite web|URL=https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/458623/20150414-MOD_Science_Capability_Review_Executive_Summary.pdf|title=A review of MOD’s science and technology capability (Executive summary)}}</ref> Following this, the commissioning role was moved to [[Defence Science and Technology]] (DST) within MOD Head Office, with Dstl focusing on delivery.{{cn}}
Within the [[Strategic Defence and Security Review 2015]] was a proposal to create "a government-backed service designed to help small and medium-sized businesses bring new ideas to market more quickly".<ref>{{Cite book|url=https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/478933/52309_Cm_9161_NSS_SD_Review_web_only.pdf|title=National Security Strategy and Strategic Defence and Security Review 2015: A Secure and Prosperous United Kingdom|date=November 2015|publisher=HM Government|isbn=9781474125963}}</ref> In 2016, it was announced by Defence Secretary [[Michael Fallon]] that this 'Defence and Security Accelerator'<ref>{{Cite web|url=https://www.gov.uk/government/organisations/defence-and-security-accelerator|title=Defence and Security Accelerator – GOV.UK|website=www.gov.uk|language=en|access-date=4 May 2018}}</ref> would have access to an £800m innovation fund and build on the 'Centre for Defence Enterprise' model, operating within Dstl.<ref>{{Cite web|url=https://www.gov.uk/government/speeches/defence-innovation-initiative|title=Defence Innovation Initiative – Speeches|website=www.gov.uk|access-date=20 September 2016}}</ref>
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