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{{More citations needed|date=March 2017}}
The '''sequential model''' (also known as the '''KNF model''') is a theory that describes [[cooperativity]] of [[protein subunit]]s.<ref name=":3"> [[Daniel E. Koshland Jr.|Koshland, D.E.]], Némethy, G. and Filmer, D. (1966) Comparison of experimental binding data and theoretical models in proteins containing subunits.
Biochemistry 5, 365–385. [http://pubs.acs.org/doi/abs/10.1021/bi00865a047 DOI: 10.1021/bi00865a047]</ref> It postulates that a protein's conformation changes with each binding of a [[Ligand (biochemistry)|ligand]], thus sequentially changing its [[chemical affinity|affinity]] for the ligand at neighboring binding sites.
[[File:KNF_model.gif|thumb|Visual representation of the KNF model in a tetrameric protein.|433x433px]]
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