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; FreeBSD
[[FreeBSD]] is not a Linux distribution, but a version of [[BSD|Unix]] that it is very similar. Its [[ports collection|ports]] are analogous Gentoo's ebuilds. However, the project continuously builds pre-compiled binary packages for Tier-1 platforms such as [[x86]] and [[ARM_architecture_family|ARM]]. There are over 240 biological sciences applications among over 2,200 scientific applications and over 31,000 ports in general. New ports and updates are listed on the Fresh Ports<ref>[http://www.freshports.org/biology/ Fresh Ports]</ref> site.
; pkgsrc
The [[pkgsrc]] package manager, originally forked from [[FreeBSD ports]], is maintained by the [[NetBSD]] project, but aims to support all [[POSIX]]-compatible operating systems. It is well-tested on [[NetBSD]], many [[Linux]] distributions, [[macOS]], and [[SunOS]] derivatives. Like FreeBSD ports, packages can be installed via pre-compiled binary packages on some platforms, or build from source on any platform, or if additional optimizations or options are desired. The collection contains over 19,000 packages in total, of which nearly 800 are in scientific categories, and over 60 are biology-related.
; Debian
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