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== Composition ==
[[File:Transitions-transversions.png|thumb|286x286px|'''Point mutation types:''' transitions (blue) are elevated compared to transversions (red) in GC-rich coding regions.<ref>(n.d.). Retrieved from <nowiki>https://www.differencebetween.com/wp-content/uploads/2017/03/Difference-Between-Transition-and-Transversion-3.png</nowiki> {{bare URL inline|date=April 2023}}</ref>]]
The evidence suggests that there is a general interdependence between base composition patterns and coding region availability.<ref>{{cite journal | vauthors = Lercher MJ, Urrutia AO, Pavlícek A, Hurst LD | title = A unification of mosaic structures in the human genome | journal = Human Molecular Genetics | volume = 12 | issue = 19 | pages = 2411–5 | date = October 2003 | pmid = 12915446 | doi = 10.1093/hmg/ddg251 | doi-access = free }}</ref> The coding region is thought to contain a higher [[GC-content]] than non-coding regions. There is further research that discovered that the longer the coding strand, the higher the GC-content. Short coding strands are comparatively still GC-poor, similar to the low GC-content of the base composition translational [[stop codon]]s like TAG, TAA, and TGA.<ref>{{cite journal | vauthors = Oliver JL, Marín A | title = A relationship between GC content and coding-sequence length | journal = Journal of Molecular Evolution | volume = 43 | issue = 3 | pages = 216–23 | date = September 1996 | pmid = 8703087 | doi = 10.1007/pl00006080 | bibcode = 1996JMolE..43..216O }}</ref>
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